Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration
| Autor: | Cédric Bossard, Yohann Wittrant, Hanna Tiainen, Henri Granel, Jonathan Lao, Christophe Vial, Edouard Jallot |
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| Přispěvatelé: | Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), University of Oslo (UiO), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Rok vydání: | 2018 |
| Předmět: |
Scaffold
Materials science [SDV]Life Sciences [q-bio] Clay industries. Ceramics. Glass 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention chemistry.chemical_compound law Materials Chemistry [CHIM]Chemical Sciences Bioactive glass Bone regeneration ComputingMilieux_MISCELLANEOUS [PHYS]Physics [physics] Synthetic bone substitute 021001 nanoscience & nanotechnology Hybrid 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Polycaprolactone TP785-869 chemistry Ceramics and Composites Medicine [SDV.IB]Life Sciences [q-bio]/Bioengineering 0210 nano-technology Biomedical engineering |
| Zdroj: | Biomedical Glasses Biomedical Glasses, 2018, 4 (1), pp.108-122. ⟨10.1515/bglass-2018-0010⟩ Biomedical Glasses, Vol 4, Iss 1, Pp 108-122 (2018) |
| ISSN: | 2299-3932 |
| DOI: | 10.1515/bglass-2018-0010⟩ |
| Popis: | Bioactive glasses (BG) bond to bone and stimulate bone regeneration, but they are brittle. Inorganicorganic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of BG with the toughness of polymers. Hybrids comprised of polycaprolactone (PCL) and SiO2-CaO BG were produced by sol-gel chemistry and processed into porous scaffolds with controlled pore and interconnection sizes. The obtained scaffolds are highly flexible, meaning that PCL effectively introduces toughness. Apatite formation is observed within 24 hours of immersion in simulated body fluid (SBF) and is not limited to the surface as the entire hybrid progressively changes into bone-like minerals. The degradation rate is suitable for bone regeneration with a 13.2% weight loss after 8 weeks of immersion. Primary osteoblasts cultured in scaffolds demonstrate that the samples are not cytotoxic and provide good cell adhesion. The in vivo study confirms the bioactivity, biocompatibility and suitable degradation rate of the hybrid. A physiological bone made of trabeculae and bone marrow regenerates. The structure and kinetic of bone regeneration was similar to the implanted commercial standard based on bovine bone, demonstrating that this new synthetic PCL-BG hybrid could perform as well as animal-derived bone substitutes. |
| Databáze: | OpenAIRE |
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