The effect of Lucilia sericata larval excretion/secretion ( ES ) products on cellular responses in wound healing
| Autor: | Umut Gazi, Aysegul Taylan-Ozkan, Kosta Y. Mumcuoglu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Chronic wound medicine.medical_treatment 030231 tropical medicine Population Physiology Lucilia 03 medical and health sciences 0302 clinical medicine Wound bed preparation Maggot therapy medicine Animals music education Ecology Evolution Behavior and Systematics Wound Healing education.field_of_study music.instrument Debridement General Veterinary biology Diptera fungi 030108 mycology & parasitology biology.organism_classification Lucilia cuprina Larva Insect Science Parasitology medicine.symptom Wound healing |
| Zdroj: | Medical and Veterinary Entomology. 35:257-266 |
| ISSN: | 1365-2915 0269-283X |
| DOI: | 10.1111/mve.12497 |
| Popis: | Chronic wounds are still regarded as a serious public health concern, which are on the increase mainly due to the changes in life styles and aging of the human population. There are different types of chronic wounds, each of which requires slightly different treatment strategies. Nevertheless, wound bed preparation is included in treatment of all types of chronic wounds and involves tissue debridement, inflammation, and infection control, as well as moisture balance and epithelial edge advancement. Maggot therapy (MT) is a form of biological debridement which involves the application of live medical grade Lucilia sericata (Meigen, 1826) (Diptera: Calliphoridae) larvae. Whereas it was initially thought to act mainly through debridement, today MT is known to influence all four overlapping physiological phases of wound repair: homeostasis, inflammation, proliferation, and remodelling/maturing. During MT, medical-grade larvae are applied either freely or enclosed in tea-bag like devices (biobag) inside the wounds, which suggests that larva excretion/secretion (ES) products can facilitate the healing processes directly without the need of direct contact with the larvae. This review summarizes the relevant literature on ES-mediated effects on the cellular responses involved in wound healing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text