Is aging preprogrammed? Observations from the brain/gut axis
| Autor: | R.-L. Zhang, Robert J Greenstein, M.M. Ybanez, William A. Bauman |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Aging medicine.medical_specialty Peptide Peptide hormone Biology digestive system Secretin Internal medicine Gene expression medicine Animals Organ weight Cholecystokinin chemistry.chemical_classification Body Weight digestive oral and skin physiology Brain Proteins Rats Inbred Strains Organ Size Rats Endocrinology medicine.anatomical_structure Gene Expression Regulation chemistry Duodenum RNA Digestive System Quantitative analysis (chemistry) Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 61:113-121 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(91)90010-w |
| Popis: | Age related differential gene expression occurs in the neuro-enteral axis. Brain and gut organ weight, total RNA, total protein and three peptides were quantified in 4-, 10- and 37-week-old Sprague-Dawley rats. As animals aged, total RNA decreased in the brain (0.65 +/- 0.3-0.28 +/- 0.03 mg/g), but remained stable in the gut (2.6 +/- 0.3-2.9 +/- 0.4 mg/g). Total protein concentration rose in the duodenum (612 +/- 28-734 +/- 34 mg/g), while levels remained stable in the brain (641 +/- 54-666 +/- 34 mg/g). Three peptides were studied, cholecystokinin (CCK), VIP and secretin. With increasing age, significant changes were found only in CCK a true neural-enteral peptide. The concentration of smaller molecular forms of CCK decreased in the brain (248 +/- 18-188 +/- 21 pmol/g), while they remained stable in the duodenum (33 +/- 2-36 +/- 3 pmol/g). By contrast, the concentration of the larger forms of CCK were stable in the brain (36 +/- 3-40 +/- 4 pmol/g), but rose in the gut (89 +/- 14-134 +/- 17 pmol/g). These data indicate that as rats age there is preprogrammed differential control of gene expression between brain and intestine. |
| Databáze: | OpenAIRE |
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