Relationship of ceftazidime pharmacokinetic indices with therapeutic outcome in patients with cystic fibrosls
| Autor: | Julie Man-Ching Hsu, Paul J. Munzenberger, Sheila J. Holliday |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Lung Diseases Male Microbiology (medical) medicine.medical_specialty Pancreatic disease Adolescent Cystic Fibrosis medicine.medical_treatment Ceftazidime Cystic fibrosis Gastroenterology Minimum inhibitory concentration Pharmacokinetics Internal medicine medicine Humans Child Chemotherapy business.industry Respiratory disease Bacterial Infections medicine.disease Surgery Pneumonia Treatment Outcome Infectious Diseases Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | The Pediatric Infectious Disease Journal. 12:997-1000 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/00006454-199312000-00007 |
| Popis: | In this study we investigated the relationships between ceftazidime pharmacokinetic indices and clinical outcome measurements during acute pulmonary exacerbations in patients with cystic fibrosis. Twenty patients received ceftazidime during the study period. On Days 2, 7 and 14 outcome measurements were assessed. Ceftazidime peaks and troughs were calculated as was the percentage of time of the dosing interval the serum concentration/minimum inhibitory concentration ratio exceeded 8, 4 and 1. There were significant differences between Days 2 and 7 and between Days 2 and 14 for the outcome measurements. There were no significant between-day differences for the pharmacokinetic indices. Significant correlations, involving both within and between study days, existed between the ceftazidime pharmacokinetic indices and the clinical outcome measurements. Further investigation of these relationships is warranted. |
| Databáze: | OpenAIRE |
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