RED-CELL MEMBRANE PROTEINS AND DIAMETER-THICKNESS RATIO IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION COMPLICATED AND NON-COMPLICATED WITH METABOLIC SYNDROME
| Autor: | Anna Sergeeva, Olesya Bogdanova, Yury Pivovarov, Lyudmila Dmitrieva |
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| Rok vydání: | 2017 |
| Předmět: |
diameter-thickness ratio
arterial hypertension medicine.medical_specialty General Immunology and Microbiology Red Cell business.industry red-cell membrane Science Spherocytosis Metabolism Hypoxia (medical) medicine.disease proteins metabolic syndrome General Biochemistry Genetics and Molecular Biology Microcirculation Endocrinology Membrane protein Internal medicine Medicine Spectrin Metabolic syndrome medicine.symptom business |
| Zdroj: | Acta Biomedica Scientifica, Vol 2, Iss 1, Pp 19-23 (2017) |
| ISSN: | 2587-9596 2541-9420 |
| DOI: | 10.12737/article_5955e6b44604e4.78416241 |
| Popis: | Change in structural and functional properties of red cell membrane proteins in patients with the essential arterial hypertension (EAH) can promote development of significant dysfunction of these cells and can complicate the course of a system hypoxia in this category of patients. The aim of our research was to determine the interrelation between red cell sphericity and the level of proteins of their membrane in patients with EAH complicated and non-complicated with metabolic syndrome (MS). 51 male patients with EAH I and II (average age - 42 ± 1.5 years) were examined and divided into 2 groups: group 1 - 29 patients with EAH complicated with MS; group 2 - 22 patients with EAH non-complicated with MS. Protein spectrum was assessed by 10 red cell membrane proteins. Results. Patients with EAH complicated with MS had decrease in spectrin level and loss of correlations between the levels of red cell membrane proteins. Number of patients with diameter-thickness ratio < 3.4 (indicates the existence of cells prone to spherocytosis) in the group 1 was twice more than in the group 2 (29.4 % vs 13.7 %). Conclusion. We determined structural and functional disorders in interrelations of such membrane proteins as a-spektrin, ATP and GAPDH (in patients with EAH complicated with MS), and ATP, GAPDH and actin (in patients with EAH non-complicated with MS) which promote development of acquired spherocytosis and further impairments in microcirculation and gaseous metabolism in tissues. |
| Databáze: | OpenAIRE |
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