Severe Coagulopathy following Intraoperative Use of Topical Thrombin
| Autor: | Daniel J. DiLorenzo, Larry W. Kraiss, Spencer W. Galt, Mark R. Sarfati |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Administration Topical macromolecular substances Postoperative Hemorrhage Severity of Illness Index Hemostatics Thrombin Refractory medicine Coagulopathy Humans Aged Aged 80 and over Prothrombin time Intraoperative Care medicine.diagnostic_test biology business.industry Factor V Bovine thrombin General Medicine Disseminated Intravascular Coagulation medicine.disease Anesthesia Prothrombin Time biology.protein Partial Thromboplastin Time Surgery Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug Partial thromboplastin time Abdominal surgery |
| Zdroj: | Annals of Vascular Surgery. 18:349-351 |
| ISSN: | 0890-5096 |
| Popis: | This report describes a case of severe coagulopathy and bleeding related to the intraoperative use of topically applied thrombin. Commercial thrombin preparations contaminated with bovine factor V have been shown to stimulate the production of antibodies directed against factor V. These antibodies can cause coagulopathy. Our patient developed antibodies against factor V after intraoperative exposure to topical thrombin. The resulting antibody-mediated depletion of factor V caused a severe and refractory coagulopathy. Vascular surgeons should be aware that the use of topical bovine thrombin can cause severe coagulopathy. |
| Databáze: | OpenAIRE |
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