Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3
| Autor: | Hickey Mj, Larry L. Deaven, Roth Gj |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Signal peptide
Leucine-rich glycoprotein family: Chromosomal localization Protein Conformation Molecular Sequence Data Restriction Mapping Biophysics Glycoprotein IX Platelet Membrane Glycoproteins Biology Biochemistry Open Reading Frames Structural Biology Complementary DNA Genetics cDNA sequence: Human platelet glycoprotein IX Humans Amino Acid Sequence Molecular Biology Gene Southern blot chemistry.chemical_classification Base Sequence Chromosome Mapping Cell Biology DNA Molecular biology Amino acid Open reading frame Chromosome 3 chemistry Genes Chromosomes Human Pair 3 |
| Zdroj: | FEBS letters. 274(1-2) |
| ISSN: | 0014-5793 |
| Popis: | Overlapping cDNAs encoding human platelet glycoprotein (Gp)IX were cloned from a human erythroleukemia cell λ gtll library. The possibly ‘full-length’ cDNA of 896 base pairs (bp) includes an open reading frame (528 bp), both 5' (222 bp) and 3' (146 bp) noncoding regions, and a poly(A) tail. Translation predicts a signal peptide of 16 amino acids and a mature protein of 160 amino acids that includes a 24 amino acid leucinerich glycoprotein (LRG) segment. Southern blot analysis suggests the presence of a single copy of the Gp IX gene, and hybridization of Gp IX cDNA to sorted human chromosomes localizes the Gp IX gene to chromosome 3. |
| Databáze: | OpenAIRE |
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