Spatiotemporal Pattern of Concurrent Spinal and Supraspinal NF-κB Expression After Peripheral Nerve Injury
| Autor: | Gordon Tin Chun Wong, Grewo Lim, Michael G. Irwin, Chiu-Wen Chou, Shuxing Wang, Jianren Mao |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Sensory system Neuropathic pain Somatosensory system NF-κB Article Functional Laterality Thalamus medicine Spinal Cord - metabolism Gene Expression Regulation - drug effects - physiology Animals Anterior cingulate cortex Pain Measurement business.industry NF-kappa B Peripheral Nervous System Diseases NF-kappa B - metabolism amygdala Somatosensory Cortex Spinal cord affective Rats anterior cingulate cortex Disease Models Animal Neuroprotective Agents Anesthesiology and Pain Medicine medicine.anatomical_structure Nociception Gene Expression Regulation Spinal Cord Neurology Synaptotagmin I Peripheral nerve injury Neuralgia Neurology (clinical) Sciatic nerve Somatosensory Cortex - metabolism Dizocilpine Maleate business Peripheral Nervous System Diseases - complications - metabolism - pathology Neuroscience |
| Zdroj: | The Journal of Pain. 12:13-21 |
| ISSN: | 1526-5900 |
| DOI: | 10.1016/j.jpain.2010.03.018 |
| Popis: | The expression of NF-κB in the spinal cord is associated with neuropathic pain. However, little is known about its expression beyond the spinal cord. Here we examined a spatial and temporal pattern of the NF-κB expression in both spinal and supraspinal regions. After chronic constriction injury (CCI) of the sciatic nerve, NF-κB (p65) expression was significantly increased in the ipsilateral spinal cord. In contrast, the NF-κB expression in the contralateral primary somatosensory cortex was decreased with no significant differences seen in the thalamus. In the contralateral anterior cingulate cortex, the NF-κB expression was increased significantly on day 14 as compared with the sham group. In the contralateral amygdala, the NF-κB expression showed a time-dependent downregulation after CCI, which became significant on day 14. MK-801 reduced nociceptive behaviors and reversed the direction of NF-κB expression. These results indicate that the CCI-induced expression of p65 NF-κB is both time-dependent and region-specific, in areas that process both sensory-discriminative and motivational-affective dimensions of pain. Perspective: This article presents a spatiotemporal mapping of the NF-κB expression in spinal and supraspinal regions after peripheral nerve injury. These findings point to an involvement of NF-κB beyond the spinal cord in both the sensory discriminative and emotional affective aspects of neuropathic pain processing. © 2011 by the American Pain Society. link_to_OA_fulltext |
| Databáze: | OpenAIRE |
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