Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review
| Autor: | Luciano Minuzzi, Sabrina K. Syan, Mara Smith, Raheem Remtulla, Benicio N. Frey, Flávio Kapczinski, Geoffrey B. Hall |
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| Rok vydání: | 2018 |
| Předmět: |
Affective Disorders
Psychotic Cingulate cortex Psychosis Bipolar Disorder Ventrolateral prefrontal cortex Rest Prefrontal Cortex Gyrus Cinguli Amygdala 03 medical and health sciences 0302 clinical medicine Parietal Lobe Neural Pathways medicine Humans Pharmacology (medical) Bipolar disorder Prefrontal cortex Biological Psychiatry Default mode network Resting state fMRI business.industry Functional Neuroimaging Remission Induction Brain medicine.disease Magnetic Resonance Imaging Frontal Lobe 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Case-Control Studies business Neuroscience 030217 neurology & neurosurgery Research Paper |
| Zdroj: | Journal of Psychiatry and Neuroscience. 43:298-316 |
| ISSN: | 1180-4882 |
| DOI: | 10.1503/jpn.170175 |
| Popis: | Background: Bipolar disorder is chronic and debilitating. Studies investigating resting-state functional connectivity in individuals with bipolar disorder may help to inform neurobiological models of illness. Methods: We conducted a systematic review with the following goals: to summarize the literature on resting-state functional connectivity in bipolar disorder during clinical remission (euthymia) compared with healthy controls; to critically appraise the literature and research gaps; and to propose directions for future research. We searched PubMed/MEDLINE, Embase, PsycINFO, CINAHL and grey literature up to April 2017. Results: Twenty-three studies were included. The most consistent finding was the absence of differences in resting-state functional connectivity of the default mode network (DMN), frontoparietal network (FPN) and salience network (SN) between people with bipolar disorder and controls, using independent component analysis. However, 2 studies in people with bipolar disorder who were positive for psychosis history reported DMN hypoconnectivity. Studies using seed-based analysis largely reported aberrant resting-state functional connectivity with the amygdala, ventrolateral prefrontal cortex, cingulate cortex and medial prefrontal cortex in people with bipolar disorder compared with controls. Few studies used regional homogeneity or amplitude of low-frequency fluctuations. Limitations: We found heterogeneity in the analysis methods used. Conclusion: Stability of the DMN, FPN and SN may reflect a state of remission. Further, DMN hypoconnectivity may reflect a positive history of psychosis in patients with bipolar disorder compared with controls, highlighting a potentially different neural phenotype of psychosis in people with bipolar disorder. Resting-state functional connectivity changes between the amygdala, prefrontal cortex and cingulate cortex may reflect a neural correlate of subthreshold symptoms experienced in bipolar disorder euthymia, the trait-based pathophysiology of bipolar disorder and/or a compensatory mechanism to maintain a state of euthymia. |
| Databáze: | OpenAIRE |
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