Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation
Autor: | Ariane R. Pessentheiner, G. Michelle Ducasa, Philip L. S. M. Gordts |
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Rok vydání: | 2020 |
Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine obesity extracellular matrix Immunology Adipose tissue Inflammation Context (language use) Review Cardiovascular Bioinformatics Oral and gastrointestinal Energy homeostasis Extracellular matrix Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Adipocytes medicine Animals Humans 2.1 Biological and endogenous factors Immunology and Allergy Chondroitin Aetiology Metabolic and endocrine Nutrition diabetes biology business.industry medicine.disease Diet metabolic inflammation Stroke 030104 developmental biology Adipose Tissue Proteoglycan chemistry Medical Microbiology biology.protein proteoglycans medicine.symptom lcsh:RC581-607 business Heparan Sulfate Proteoglycans 030215 immunology |
Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
ISSN: | 1664-3224 |
Popis: | Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in metabolic homeostasis and meta-inflammation. Over the last decade, new insights have emerged on the mechanism and biological significance of these interactions in the context of diet-induced disorders such as obesity and type-2 diabetes. Complications of energy metabolism drive most diet-induced metabolic disorders, which results in low-grade chronic inflammation, thereby affecting proper function of many vital organs involved in energy homeostasis, such as the brain, liver, kidney, heart and adipose tissue. Here, we discuss how heparan, chondroitin and keratan sulfate proteoglycans modulate obesity-induced metabolic dysfunction and low-grade inflammation that impact the initiation and progression of obesity-associated morbidities. |
Databáze: | OpenAIRE |
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