The prognostic significance of autologous bone marrow transplant in advanced neuroblastoma
| Autor: | Robert P. Castleberry, Nancy B. McWilliams, John Graham Pole, Robert Marcus, Jonathan J. Shuster, E I Smith, Alan B. Cantor, Terry Pick, F A Hayes |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Pilot Projects Transplantation Autologous law.invention Neuroblastoma Randomized controlled trial law Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Cyclophosphamide Bone Marrow Transplantation Podophyllotoxin Chemotherapy business.industry Remission Induction Infant Autologous bone medicine.disease Prognosis Combined Modality Therapy Surgery Survival Rate medicine.anatomical_structure Oncology Bone transplantation El Niño Doxorubicin Child Preschool Female Bone marrow Cisplatin business Childhood Neuroblastoma |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 9(6) |
| ISSN: | 0732-183X |
| Popis: | This report provides strong evidence for conducting a controlled randomized clinical trial of autologous bone marrow transplantation versus conventional chemotherapy in childhood neuroblastoma, which is disseminated beyond the intracavity nodes, and which is diagnosed in children older than 12 months of age. On the basis of two Pediatric Oncology Group (POG) studies, one a surgery plus conventional chemotherapy study (POG 8441) and the other an elective autologous transplant pilot protocol (POG 8340), there was no significant prognostic benefit of switching in remission from the surgery plus chemotherapy protocol to the transplant protocol (P = .91) or of switching in remission from the surgery plus chemotherapy protocol to any transplant (P = .75). The analysis is based on 116 patients achieving a complete or partial remission, 32 of whom received transplants on the pilot protocol, and 17 of whom received transplants outside the pilot protocol. While potential selection bias precludes cause-effect conclusions, these data strongly suggest that a large randomized trial of autologous bone marrow transplantation should be conducted before accepting this form of therapy as standard. |
| Databáze: | OpenAIRE |
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