New insights on strain-specific impacts of probiotics on insulin resistance: evidence from animal study
| Autor: | Nazarii Kobyliak, Liudmila Ostapchenko, Dmytro Kyriienko, Tetyana Falalyeyeva, Olena Tsyryuk, Tetyana Beregova, Majid Eslami |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Monosodium glutamate Endocrinology Diabetes and Metabolism Propionibacterium law.invention 03 medical and health sciences Probiotic chemistry.chemical_compound 0302 clinical medicine Insulin resistance law Internal medicine Lactobacillus Diabetes mellitus Internal Medicine medicine Bifidobacterium biology Adiponectin business.industry biology.organism_classification medicine.disease 030104 developmental biology Endocrinology chemistry 030211 gastroenterology & hepatology business Research Article |
| Zdroj: | J Diabetes Metab Disord |
| ISSN: | 2251-6581 |
| DOI: | 10.1007/s40200-020-00506-3 |
| Popis: | BACKGROUND AND AIMS: сomparative animal study of effectiveness of intermittent administration of lyophilized single-, three- and alive multistrain probiotic in short courses on insulin resistance (IR) in rats with experimental obesity. METHODS: 70 rats were divided into 7 groups (n = 10 in each). Rats of group I were left intact. Newborn rats in groups II-VII were administered monosodium glutamate (MSG) (4 mg/g) by injection. Rats in group II (MSG-obesity group) were left untreated. The rats in groups III-V received lyophilized mono-probiotics B.animalis VKL, B.animalis VKB, L.casei IMVB-7280 respectively. The rats in group VI received all three of these probiotic strains mixed together. Group VII was treated with multi-probiotic “Symbiter”, containing 14 different live probiotic strains (Lactobacillus, Bifidobacterium, Propionibacterium, Acetobacter genera). RESULTS: Treatment of newborn rats with MSG lead to the development of obesity in all MSG-obesity rats and up to 20–70% after probiotic administration. Additions to probiotic composition, with preference to alive strains (group VII), led to significantly lower rates of obesity, decrease in HOMA-IR (p |
| Databáze: | OpenAIRE |
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