Infantile atypical subependymal giant cell astrocytoma
| Autor: | Essam AlShail, Jamal Abdullah, Abdulaziz O. Almubarak, Hindi Al Hindi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Case Report Astrocytoma Intraventricular tumor Complete resection Tuberous sclerosis Midline shift Tuberous Sclerosis medicine Humans Craniotomy Subependymal giant cell astrocytoma business.industry Clinical course Infant medicine.disease Psychiatry and Mental health Neurology (clinical) Neoplasm Recurrence Local Glioblastoma business Cerebral Ventricle Neoplasms |
| Zdroj: | Neurosciences |
| ISSN: | 1658-3183 |
| DOI: | 10.17712/nsj.2020.1.20190044 |
| Popis: | Subependymal giant cell astrocytoma is a benign WHO grade I intraventricular tumor arise in patients with tuberous sclerosis complex. Previous reported described histopathological predictors of more aggressive forms, terms atypical SEGA in infantile age group. Other reports showed possible transformation of SEGA into glioblastoma, or misdiagnosis as glioblastoma due to the presence of atypical histopathological features. Here, we report a case of an infant who presented with right frontal extraventricular SEGA and underwent craniotomy with complete resection. Eight months later, he presented with fast recurrence in same location with midline shift and subfalcine herniation. Histopathological description showed high grade features including Ki labeling index of 60%, atypical mitotic figures, cellular plemorphism and necrosis. We also discussed the possible presence of different entity (termed atypical SEGA) which may have more aggressive clinical course, with literature review of predictors of SEGA aggressiveness and possible transformation/misdiagnosis as glioblastoma. |
| Databáze: | OpenAIRE |
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