Monoclonal immunoglobulin rescue from a patient with chronic lymphocytic leukemia and autoimmune hemolytic anemia
| Autor: | Karol Sikora, John G. Krikorian, Ronald Levy |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Erythrocytes
Chronic lymphocytic leukemia Immunology Receptors Antigen B-Cell Hybrid Cells Biochemistry Antigen Medicine Humans Aged Autoantibodies Red Cell biology business.industry Autoantibody Cell Biology Hematology medicine.disease Leukemia Lymphoid Myeloma Proteins Immunoglobulin M Concomitant biology.protein Female Anemia Hemolytic Autoimmune Autoimmune hemolytic anemia Antibody business Clone (B-cell biology) |
| Zdroj: | Blood. 54:513-518 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v54.2.513.bloodjournal542513 |
| Popis: | In order to test whether autoimmune hemolytic anemia in a patient with chronic lymphocytic leukemia was due to autoantibody production by the neoplastic clone, somatic cell hybrids were constructed between the patient's leukemic cells and a mouse myeloma line. Light-chain- restricted human immunoglobulin was secreted by 4 of 11 of the established hybrid lines. No binding of this immunoglobulin to red cell surface antigens could be detected. Thus, we conclude that the autoantibody in this patient represented a concomitant reactive response and was not the product of the malignant clone of B cells. |
| Databáze: | OpenAIRE |
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