Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves
| Autor: | Sonja B. Hofer, Isabelle Cloëz-Tayarani, Tobias Bonhoeffer, Mark Hübener, Jean-Pierre Changeux, Thomas D. Mrsic-Flogel, Claire Creutzfeldt |
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| Přispěvatelé: | Max-Planck-Institut für Neurobiologie (MPIN), Max-Planck-Gesellschaft, Récepteurs et Cognition (RC), Collège de France (CdF (institution))-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Collège de France (CdF (institution))-Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2005 |
| Předmět: |
Retinal Ganglion Cells
Superior Colliculi MESH: Mice Mutant Strains [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Visual space Development/Plasticity/Repair Receptors Nicotinic Visual system Biology Retinal ganglion Retina Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine MESH: Mice Inbred C57BL medicine Animals Visual Pathways MESH: Animals MESH: Mice MESH: Brain Mapping 030304 developmental biology Brain Mapping MESH: Visual Pathways 0303 health sciences MESH: Retina General Neuroscience Superior colliculus MESH: Superior Colliculi MESH: Retinal Ganglion Cells Retinal Mice Mutant Strains Retinal waves Mice Inbred C57BL medicine.anatomical_structure chemistry MESH: Receptors Nicotinic Axon guidance Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2005, 25 (29), pp.6921-8. ⟨10.1523/JNEUROSCI.1555-05.2005⟩ Journal of Neuroscience, 2005, 25 (29), pp.6921-8. ⟨10.1523/JNEUROSCI.1555-05.2005⟩ |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1555-05.2005 |
| Popis: | During the development of the mammalian retinocollicular projection, a coarse retinotopic map is set up by the graded distribution of axon guidance molecules. Subsequent refinement of the initially diffuse projection has been shown to depend on the spatially correlated firing of retinal ganglion cells. In this scheme, the abolition of patterned retinal activity is not expected to influence overall retinotopic organization, but this has not been investigated. We used optical imaging of intrinsic signals to visualize the complete retinotopic map in the superior colliculus (SC) of mice lacking early retinal waves, caused by the deletion of the β2 subunit of the nicotinic acetylcholine receptor. As expected from previous anatomical studies in the SC of β2-/-mice, regions activated by individual visual stimuli were much larger and had less sharp borders than those in wild-type mice. Importantly, however, we also found systematic distortions of the entire retinotopic map: the map of visual space was expanded anteriorly and compressed posteriorly. Thus, patterned neuronal activity in the early retina has a substantial influence on the coarse retinotopic organization of the SC. |
| Databáze: | OpenAIRE |
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