The changes in pyroptosis-related inflammatory factors in the peripheral blood of patients with Henoch-Schonlein purpura
| Autor: | Fen Lian, Wanhong Ke, Genwang Chen, Chunmei Fan, Jinpeng Wang, Daqi Jiang, Yiming Lv, Lili Liu, Yuyu Zheng, Sisi Gong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Henoch-Schonlein purpura IgA Vasculitis medicine.medical_treatment Caspase 1 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pyroptosis Humans Glucocorticoids Advanced and Specialized Nursing Proteinuria business.industry Interleukin medicine.disease Peripheral Regimen 030104 developmental biology Anesthesiology and Pain Medicine Interleukin 18 Hormone therapy medicine.symptom business |
| Zdroj: | Annals of palliative medicine. 10(6) |
| ISSN: | 2224-5839 |
| Popis: | Henoch-Schonlein purpura (HSP) is a common capillary allergic bleeding disease. To explore the variation of pyroptosis-related inflammatory factors level in the peripheral blood of patients with HSP.A total of 87 HSP patients treated in our hospital from June 2020 to March 2021 were selected and divided into the renal impairment group (n=29) and the non-renal impairment group (n=58) according to the presence of hematuria and proteinuria. A total of 50 healthy individuals from the hospital were selected as the control group. The renal impairment and non-renal impairment groups were treated with a regular regimen of compound glycyrrhizin tablets and glucocorticoids, respectively. Serum interleukin (IL)-18, IL-1β, and peripheral caspase-1-positive cells were compared pre- and post-treatment among the three groups.The pre-treatment serum IL-1β levels in the renal impairment and non-renal impairment groups were significantly higher than that in the control group (P0.01). After treatment, the IL-1β level in the non-renal impairment group was not significantly different from that in the control group (P0.05). However, the IL-1β level in the renal impairment group post-treatment was significantly higher than that in the other two groups (P0.01). The positive rate of caspase-1 expression in peripheral blood before treatment in the renal impairment group and non-renal impairment group was significantly higher than that in the control group (P0.01). After treatment, the positive rate of caspase-1 expression in the non-renal impairment group was comparable to that in the control group (P0.05), whereas the rate in the renal impairment group was significantly higher than that in the other two groups (P0.01). After treatment, the serum IL-1β levels and caspase-1 positive rate in HSP patients who were responsive to treatment (as assessed by hematuria or proteinuria levels after treatment) were lower than that in patients who were unresponsive to treatment P0.001), but not significantly different to the control group (P0.05).The levels of serum IL-1β and caspase-1 changed in response to alterations in the disease condition and treatment response in HSP patients, which suggested that pyroptosis-related inflammatory factors may have potential application value in predicting disease progression and efficacy of hormone therapy. |
| Databáze: | OpenAIRE |
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