Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort
| Autor: | Jason Viner, Ed Moran, Marie Attwood, Samuel Gunning, Jessica Hatrick, Alice Milne, Shaney L Barratt, Huzaifa Adamali, Anna Bibby, Fergus Hamilton, Alan R. Noel, Sassa Hamilton, David T Arnold, Nick A Maskell, Anna J Morley, James W. Dodd, Karen T Elvers, Catherine Hyams |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Adult Male Pediatrics medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment Physical examination Brief Communication Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Quality of life respiratory infection Oxygen therapy medicine Blood test Humans 030212 general & internal medicine Prospective Studies Pandemics Aged Rehabilitation medicine.diagnostic_test business.industry SARS-CoV-2 Respiratory infection COVID-19 Covid19 Middle Aged United Kingdom Hospitalization Cohort Observational study Female viral infection Chest radiograph business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Thorax Arnold, D T, Hamilton, F W, Milne, A, Morley, A J, Viner, J, Attwood, M, Noel, A, Gunning, S, Hatrick, J, Hamilton, S, Elvers, K T, Hyams, C, Bibby, A, Moran, E, Adamali, H I, Dodd, J W, Maskell, N A & Barratt, S L 2020, ' Patient outcomes after hospitalisation with COVID-19 and implications for follow-up : results from a prospective UK cohort ', Thorax . https://doi.org/10.1136/thoraxjnl-2020-216086 |
| ISSN: | 1468-3296 0040-6376 |
| Popis: | BackgroundCOVID-19 causes a wide spectrum of disease. The incidence and severity of sequelae after the acute infection is uncertain. Data measuring the longer-term impact of COVID-19 on symptoms, radiology and pulmonary function are urgently needed to plan follow-up services.MethodsConsecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study with outcomes recorded at 28-days. All were invited to a systematic follow up at 8-12 weeks, including chest radiograph, spirometry, exercise test, bloods, and health-related quality of life (HRQoL) questionnaires.FindingsBetween 30th March and 3rd June 2020, 163 patients with COVID-19 were recruited. Median hospital length of stay was 5 days (IQR 2-8) and 19 patients died. At 8-12 weeks post admission, 134 patients were available for follow up and 110 attended. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) with reduced HRQoL.Only patients who required oxygen therapy in hospital had abnormal radiology, clinical examination or spirometry at follow up. Thirteen (12%) patients had an abnormal chest X-ray with improvement in all but 2 from admission. Eleven (10%) had restrictive spirometry. Blood test abnormalities had returned to baseline in the majority (104/110).InterpretationPatients with COVID-19 remain highly symptomatic at 8-12 weeks, however, clinical abnormalities requiring action are infrequent, especially in those without a supplementary oxygen requirement during their acute illness. This has significant implications for physicians assessing patients with persistent symptoms, suggesting that a more holistic approach focussing on rehabilitation and general wellbeing is paramount.FundingSouthmead Hospital Charity |
| Databáze: | OpenAIRE |
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