Infection History and Current Coinfection With Schistosoma mansoni Decreases Plasmodium Species Intensities in Preschool Children in Uganda

Autor:	Daniel McDowell, Lisa Hurt, Narcis B Kabatereine, John Russell Stothard, Joanne Lello
Rok vydání:	2021
Předmět:	Plasmodium Coinfection wa_395 wc_810 Schistosoma mansoni Schistosomiasis mansoni Malaria Infectious Diseases qx_135 Child Preschool parasitic diseases Schistosoma haematobium Immunology and Allergy Animals Humans Uganda ws_440
Zdroj:	The Journal of infectious diseases. 225(12)
ISSN:	1537-6613 0022-1899
Popis:	Malaria–schistosomiasis coinfections are common in sub-Saharan Africa but studies present equivocal results regarding the interspecific relationships between these parasites. Through mixed-model analyses of a dataset of Ugandan preschool children, we explore how current coinfection and prior infection with either Schistosoma mansoni or Plasmodium species alter subsequent Plasmodium intensity, Plasmodium risk, and S mansoni risk. Coinfection and prior infections with S mansoni were associated with reduced Plasmodium intensity, moderated by prior Plasmodium infections, wealth, and host age. Future work should assess whether these interactions impact host health and parasite control efficacy in this vulnerable age group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288bc0479331061b8046edba1a9dae70 https://pubmed.ncbi.nlm.nih.gov/35245932 Zobrazit plný text záznamu