Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant: Rabbit-rat experiments
| Autor: | Shuji Ikebe, Kei Shimizu, Shogo Masumi, Tsutana Fukunaga, Hirokazu Yano |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphocyte Transplantation Heterologous Tacrolimus Osteogenesis medicine Animals Potency Orthopedics and Sports Medicine Rats Wistar Bone Transplantation Lagomorpha biology business.industry Rabbit rat biology.organism_classification medicine.disease Lymphocyte Subsets Pathophysiology Rats Transplantation medicine.anatomical_structure Immunology Surgery Rabbits CD5 business Infiltration (medical) Immunosuppressive Agents |
| Zdroj: | Acta Orthopaedica Scandinavica. 66:557-560 |
| ISSN: | 0001-6470 |
| DOI: | 10.3109/17453679509002315 |
| Popis: | We investigated osteogenesis and lymphocyte subsets in xenogeneic bone transplantation, using the immunosuppressant FK506 (FK). Iliac bones of rabbits were transplanted as fresh and frozen xenogeneic bone grafts into an intramuscular pouch of rats. FK was injected intramuscularly in half of the rats in a dose of 3 mg/kg/day for 14 days after transplantation. At 2, 4, and 8 weeks, transplanted grafts and the lymphocyte subsets of these rats were examined. In the group not given FK, the grafted bone became necrotic and infiltrated with small round cells around the trabeculae. In the FK group, at 2 and 4 weeks, new bone was formed in the fresh xenografts without infiltration of lymphocytes. At 8 weeks, the new bone became necrotic and lymphocytes were present. The percentage of T cells (CD 5), B cells and the ratio of CD 4 cells/CD 8 cells were smaller in the FK group. Using an immunosuppressant we concluded that xenogeneic bone has an osteogeneic potency. |
| Databáze: | OpenAIRE |
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