Long term term follow-up of tyrosine kinase inhibitors treatments in inoperable or relapsing diffuse type tenosynovial giant cell tumors (dTGCT)
| Autor: | Sylvie Chabaud, Gualter Vaz, Aurélien Dupré, Jean-Yves Blay, Philippe A. Cassier, Jerome Garret, Marie Karanian, Isabelle Ray-Coquard, Mehdi Brahmi, François Gouin, Armelle Dufresne, Nadège Corradini, Amine Bouhamama, David Pérol, Marie-Pierre Sunyach, Perrine Marec-Berard, Alexandra Meurgey |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Kinase Inhibitors Cancer Treatment Synovitis Pigmented Villonodular Single Center Biochemistry Giant Cells Antineoplastic Agents Immunological 0302 clinical medicine Animal Cells Medicine and Health Sciences Medicine 030212 general & internal medicine Enzyme Inhibitors Young adult Multidisciplinary Middle Aged Tumor Resection Institutional review board 3. Good health Surgical Oncology Treatment Outcome Oncology Connective Tissue 030220 oncology & carcinogenesis Female Cellular Types Anatomy Research Article medicine.drug Clinical Oncology Adult medicine.medical_specialty Adolescent Science Pexidartinib Surgical and Invasive Medical Procedures Tyrosine Kinase Inhibitors Young Adult 03 medical and health sciences Humans Protein Kinase Inhibitors Survival analysis Retrospective Studies Surgical Resection business.industry Biology and Life Sciences Retrospective cohort study Imatinib Cell Biology Survival Analysis Surgery Biological Tissue Nilotinib Enzymology Clinical Medicine Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 5, p e0233046 (2020) |
| ISSN: | 1932-6203 |
| Popis: | Rationale CSF1R tyrosine kinase inhibitors (TKI) and antibodies yield response rates and tumor control in patients with diffuse type tenosynovial giant cell tumors (dTGCT). The long term management of patients with dTGCT treated with TKI is however not known. Patients and methods We conducted a retrospective single center study on the 39 patients with advanced and/or inoperable dTGCT referred to the Centre Leon Berard for a medical treatment. The clinical characteristics and treatments of patients who had received at least one line of CSF1R TKI or Ab was collected from the electronic patient records and analyzed, after this study was approved by the Institutional Review Board of the Centre Leon Berard. Statistics were conducted using SPSS 23.0. Results Thirty-nine patients received at least one line of TKI among the 101 patients with histologically confirmed dTGCT refered to this center. Imatinib, nilotinib, pexidartinib, emactuzumab were the most frequently used agents. First line treatment was given for a median duration of 7 months. With a median follow-up from the initiation of TKI of 30 months, the progression-free rate at 30 months is 56% for the 39 patients. 15 patients had recurrent disease after first line CSF1R inhibitor: 12 (80%) received a 2nd line treatment for a median duration of 6 months and a median time to progression (TTP) of 12 months. Six patients had afterwards a recurrent disease and 5 (83%) received a 3rd line treatment for a median duration of 5 months and a median TTP of 9 months. Progression-free rate at 30 months was observed in 3 of 12 (25%) after line 2 and 1 of 5 (20%) after line 3. None of the patients refered died with a median follow-up of 67 months. Conclusions CSF1R TKI or Ab provide prolonged tumor control and symptom relief for a majority of patients with inoperable or relapsing dTGCT, in first and subsequent lines. Multiple lines are required for close to 50% of patients with relapsing dTGCT. |
| Databáze: | OpenAIRE |
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