A Novel Regulatory Role of Activated Leukocyte Cell-Adhesion Molecule in the Pathogenesis of Pulmonary Fibrosis
| Autor: | Mi Na Kim, Jung Yeon Hong, Eun Gyul Kim, Jae Woo Lee, Soo Yeon Lee, Kyung Won Kim, Hyo Sup Shim, Chun Geun Lee, Jack A. Elias, Yong Ju Lee, Myung Hyun Sohn |
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| Rok vydání: | 2022 |
| Předmět: |
Fetal Proteins
Pulmonary and Respiratory Medicine Cell Adhesion Molecules Neuronal Clinical Biochemistry Cell Biology Idiopathic Pulmonary Fibrosis Mice Inbred C57BL Transforming Growth Factor beta1 Bleomycin Mice Phosphatidylinositol 3-Kinases Antigens CD Activated-Leukocyte Cell Adhesion Molecule Leukocytes Animals Humans Lung Molecular Biology |
| Zdroj: | American Journal of Respiratory Cell and Molecular Biology. 66:415-427 |
| ISSN: | 1535-4989 1044-1549 |
| DOI: | 10.1165/rcmb.2020-0581oc |
| Popis: | Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by fibroproliferative matrix molecule accumulation, collagen deposition, and apoptosis. Activated leukocyte cell-adhesion molecule (ALCAM; CD166) is a cell-adhesion molecule that has been implicated in adhesive and migratory attribution, including leukocyte homing and trafficking and cancer metastasis. We investigated the role of ALCAM on pulmonary fibrosis development in murine models. Thus, a bleomycin-induced pulmonary fibrosis model was established with wild-type and ALCAM |
| Databáze: | OpenAIRE |
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