Emphysema Index Based on Hyperpolarized
| Autor: | Gordon D. Cates, Chengbo Wang, Alan M Ropp, Eduard E. de Lange, Sina Tafti, Jaime F. Mata, Y. Michael Shim, Talissa A. Altes, William J. Garrison, G. Wilson Miller, John P. Mugler |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Hyperpolarized Helium 3 Helium 030218 nuclear medicine & medical imaging Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Diffusing capacity Effective diffusion coefficient Medicine Humans Radiology Nuclear Medicine and imaging Lung volumes Lung Original Research Emphysema COPD business.industry Middle Aged medicine.disease Magnetic Resonance Imaging Confidence interval respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Pulmonary Emphysema 030220 oncology & carcinogenesis Case-Control Studies Xenon Isotopes Female Nuclear medicine business Tomography X-Ray Computed |
| Zdroj: | Radiology |
| ISSN: | 1527-1315 |
| Popis: | BACKGROUND: Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases have shown promise in the characterization of emphysema in patients with chronic obstructive pulmonary disease (COPD), yet an easily interpreted quantitative metric beyond mean and standard deviation has not been established. PURPOSE: To introduce a quantitative framework with which to characterize emphysema burden based on hyperpolarized helium 3 ((3)He) and xenon 129 ((129)Xe) ADC maps and compare its diagnostic performance with CT-based emphysema metrics and pulmonary function tests (PFTs). MATERIALS AND METHODS: Twenty-seven patients with mild, moderate, or severe COPD and 13 age-matched healthy control subjects participated in this retrospective study. Participants underwent CT and multiple b value diffusion-weighted (3)He and (129)Xe MRI examinations and standard PFTs between August 2014 and November 2017. ADC-based emphysema index was computed separately for each gas and b value as the fraction of lung voxels with ADC values greater than in the healthy group 99th percentile. The resulting values were compared with quantitative CT results (relative lung area 0.99) and strongly correlated with quantitative CT (r = 0.86, P < .001 for (3)He; r = 0.85, P < .001 for (129)Xe) with high AUC (≥0.93; 95% confidence interval [CI]: 0.85, 1.00). ADC emphysema indices were also correlated with percentage of predicted diffusing capacity of lung for carbon monoxide (r = −0.81, P < .001 for (3)He; r = −0.80, P < .001 for (129)Xe) and percentage of predicted residual lung volume divided by total lung capacity (r = 0.65, P < .001 for (3)He; r = 0.61, P < .001 for (129)Xe). CONCLUSION: Emphysema index based on hyperpolarized helium 3 or xenon 129 diffusion MRI provides a repeatable measure of emphysema burden, independent of gas or b value, with similar diagnostic performance as quantitative CT or pulmonary function metrics. © RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Schiebler and Fain in this issue. |
| Databáze: | OpenAIRE |
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