Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod
Autor: | Yannick Goumon, Jorge E. Mendoza, Daniel Clesse, Eus J.W. Van Someren, Jacob Itzhacki |
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Přispěvatelé: | Integrative Neurophysiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Royal Netherlands Academy of Arts and Sciences (KNAW), Laboratoire de neurosciences cognitives et adaptatives (LNCA), Vrije Universiteit Amsterdam [Amsterdam] (VU), MENDOZA, Jorge, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), APH - Mental Health, Psychiatry, Netherlands Institute for Neuroscience (NIN) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Histology Light [SDV]Life Sciences [q-bio] Dopamine Rodentia Biology Nucleus accumbens Striatum 03 medical and health sciences 0302 clinical medicine Reward Internal medicine Mood Journal Article medicine Animals Circadian rhythm Clock genes Chromatography High Pressure Liquid ComputingMilieux_MISCELLANEOUS Analysis of Variance Suprachiasmatic nucleus General Neuroscience Dopaminergic Circadian Brain Seasonal Affective Disorder Phototherapy Circadian Rhythm [SDV] Life Sciences [q-bio] CLOCK PER2 Disease Models Animal Light intensity 030104 developmental biology Endocrinology Arvicanthis 3 4-Dihydroxyphenylacetic Acid Seasons Anatomy Locomotion 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Brain Structure and Function Brain Structure and Function, 2018(6), 1-12. Springer Verlag Brain Structure and Function, 2018, 223 (6), pp.2641-2652. ⟨10.1007/s00429-018-1655-8⟩ Brain Structure and Function, Springer Verlag, 2018, 223 (6), pp.2641-2652. ⟨10.1007/s00429-018-1655-8⟩ Itzhacki, J, Clesse, D, Goumon, Y, van Someren, E J & Mendoza, J 2018, ' Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod ', Brain Structure and Function, vol. 2018, no. 6, pp. 1-12 . https://doi.org/10.1007/s00429-018-1655-8 Brain Structure and Function, 223(6), 2641-2652. Springer Verlag Brain Structure and Function, 223, 2641-2652. Springer Verlag GmbH Itzhacki, J, Clesse, D, Goumon, Y, Van Someren, E J & Mendoza, J 2018, ' Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod ', Brain Structure and Function, vol. 223, no. 6, pp. 2641-2652 . https://doi.org/10.1007/s00429-018-1655-8 |
ISSN: | 1863-2653 1863-2661 |
Popis: | International audience; Seasonal affective disorder (SAD), beyond mood changes, is characterized by alterations in daily rhythms of behavior and physiology. The pathophysiological conditions of SAD involve changes in day length and its first-line treatment is bright light therapy. Animal models using nocturnal rodents have been studied to elucidate the neurobiological mechanisms of depression, but might be ill suited to study the therapeutic effects of light in SAD since they exhibit light-aversive responses. Here Arvicanthis ansorgei, a diurnal rodent, was used to determine behavioral, molecular and brain dopamine changes in response to exposure to a winter-like photoperiod consisting of a light-dark cycle with 8 h of light, under diminished light intensity, and 16 h of darkness. Furthermore, we evaluated whether timed-daily bright light exposure has an effect on behavior and brain physiology of winter-like exposed animals. Arvicanthis under a winter-like condition showed alterations in the synchronization of the locomotor activity rhythm to the light-dark cycle. Moreover, alterations in day-night activity of dopaminergic neurotransmission were revealed in the nucleus accumbens and the dorsal striatum, and in the day-night clock gene expression in the suprachiasmatic nucleus. Interestingly, whereas dopamine disturbances were reversed in animals exposed to daily light at early or late day, altered phase of the daily rhythm of locomotion was reverted only in animals exposed to light at the late day. Moreover, Per2 gene expression in the SCN was also affected by light exposure at late day in winter-like exposed animals. These findings suggest that light induces effects on behavior by mechanisms that rely on both circadian and rhythm-independent pathways influencing the dopaminergic circuitry. This last point might be crucial for understanding the mechanisms of non-pharmacological treatment in SAD. |
Databáze: | OpenAIRE |
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