Successful Treatment of Dermatomyositis During Pregnancy With Intravenous Immunoglobulin Monotherapy
Autor: | Lucy A. Bayer-Zwirello, Kenneth C. Gorson, Peter Y. Chang, Lloyd B. Williams, Ellen Park |
---|---|
Rok vydání: | 2007 |
Předmět: |
Adult
medicine.medical_specialty Gastroenterology Dermatomyositis Drug Administration Schedule Diagnosis Differential Pregnancy Prenatal Diagnosis Internal medicine Immunopathology medicine Humans Adverse effect Creatine Kinase biology business.industry Standard treatment Infant Newborn Immunoglobulins Intravenous Obstetrics and Gynecology medicine.disease Connective tissue disease Surgery Pregnancy Complications Pregnancy Trimester First biology.protein Gestation Female Creatine kinase business |
Zdroj: | Obstetrics & Gynecology. 109:561-563 |
ISSN: | 0029-7844 |
DOI: | 10.1097/01.aog.0000253244.45837.7c |
Popis: | Background Dermatomyositis is rare during pregnancy and, if untreated, is associated with poor fetal outcome. Corticosteroids are a standard treatment for dermatomyositis in pregnancy, but they have adverse effects. Intravenous immune globulin is an effective therapy for this condition and may have few adverse effects. Case A young, white primigravida presented with dermatomyositis at 4 5/7 weeks of gestation (creatine kinase 2,762 units/L). Intravenous immune globulin was administered monthly at a dose of 1 g/(kg.d) for 2 consecutive days. The patient's symptoms resolved and no complications were experienced during therapy. At term, creatine kinase was 29 units/L and a healthy 3,657.5-g (8-lb, 1-oz) neonate was born. Conclusion Pregnant patients with dermatomyositis can be treated with intravenous immune globulin, resulting in good fetal outcome, thus avoiding the deleterious effects of corticosteroid therapy on pregnancy. |
Databáze: | OpenAIRE |
Externí odkaz: |