Successful Treatment of Dermatomyositis During Pregnancy With Intravenous Immunoglobulin Monotherapy

Autor: Lucy A. Bayer-Zwirello, Kenneth C. Gorson, Peter Y. Chang, Lloyd B. Williams, Ellen Park
Rok vydání: 2007
Předmět:
Zdroj: Obstetrics & Gynecology. 109:561-563
ISSN: 0029-7844
DOI: 10.1097/01.aog.0000253244.45837.7c
Popis: Background Dermatomyositis is rare during pregnancy and, if untreated, is associated with poor fetal outcome. Corticosteroids are a standard treatment for dermatomyositis in pregnancy, but they have adverse effects. Intravenous immune globulin is an effective therapy for this condition and may have few adverse effects. Case A young, white primigravida presented with dermatomyositis at 4 5/7 weeks of gestation (creatine kinase 2,762 units/L). Intravenous immune globulin was administered monthly at a dose of 1 g/(kg.d) for 2 consecutive days. The patient's symptoms resolved and no complications were experienced during therapy. At term, creatine kinase was 29 units/L and a healthy 3,657.5-g (8-lb, 1-oz) neonate was born. Conclusion Pregnant patients with dermatomyositis can be treated with intravenous immune globulin, resulting in good fetal outcome, thus avoiding the deleterious effects of corticosteroid therapy on pregnancy.
Databáze: OpenAIRE