Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir

Autor: Massimo Andreoni, Carlotta Cerva, Elisabetta Teti, Livio Pupo, Maria Cantonetti, Alfredo Pennica, Laura Campogiani, Gaetano Maffongelli, Sara Vaccarini, Loredana Sarmati
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Ganciclovir
Adult
Male
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty
Settore MED/17 - Malattie Infettive
Pyridones
030106 microbiology
Viremia
HIV Infections
Case Report
Primary effusion lymphoma
Emtricitabine
Tenofovir alafenamide
Gastroenterology
Piperazines
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Dolutegravir
HHV8
Virology
Internal medicine
Lymphoma
Primary Effusion
Oxazines
Medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
business.industry
Remission Induction
Chorioretinitis
virus diseases
Herpesviridae Infections
medicine.disease
Lymphoma
chemistry
Anti-Retroviral Agents
Positron-Emission Tomography
Herpesvirus 8
Human
Molecular Medicine
business
lcsh:RC581-607
Heterocyclic Compounds
3-Ring
medicine.drug
Zdroj: AIDS Research and Therapy, Vol 16, Iss 1, Pp 1-7 (2019)
AIDS Research and Therapy
ISSN: 1742-6405
Popis: Background Human herpes virus 8 (HHV8) is the causative agent of Kaposi’s sarcoma and has been associated with an increasing number of hematologic diseases such as primary effusion lymphoma (PEL) (both classic and extracavitary form), multicentric Castleman disease and the germinotropic lymphoproliferative disorder. PEL is a rare B cell non-Hodgkin lymphoma that primarily affects immunocompromised patients; aggressive chemotherapy and antiretroviral therapy (ART) with protease inhibitors have been used, with poor results. We present a case of extracavitary PEL in an HIV-infected patient, regressed after ART initiation. Case presentation A 42-year-old male was admitted to the emergency room because of several months of malaise, fever and progressive deterioration of the general conditions. On physical examination soft non-painful subcutaneous masses were palpable at retronuchal, retroauricolar and thoracic regions. HIV serology resulted positive: HIV plasma viremia was 782,270 copies/mL, CD4 103 cells/mL. The excision of one of the masses, metabolically active at a positron emission tomography (PET-CT) scan, revealed an HHV8-related extracavitary PEL. HHV8 plasma viremia was 44,826 copies/mL. ART with tenofovir alafenamide/emtricitabine/dolutegravir was started together with ganciclovir for cytomegalovirus chorioretinitis. The progressive disappearance of the masses was seen after 6 weeks of ART, and a PET-CT scan resulted completely negative at 3 months. After 19 months of ART the patient was in remission of PEL, HIV viremia was undetectable (
Databáze: OpenAIRE
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