Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir
Autor: | Massimo Andreoni, Carlotta Cerva, Elisabetta Teti, Livio Pupo, Maria Cantonetti, Alfredo Pennica, Laura Campogiani, Gaetano Maffongelli, Sara Vaccarini, Loredana Sarmati |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Ganciclovir Adult Male lcsh:Immunologic diseases. Allergy medicine.medical_specialty Settore MED/17 - Malattie Infettive Pyridones 030106 microbiology Viremia HIV Infections Case Report Primary effusion lymphoma Emtricitabine Tenofovir alafenamide Gastroenterology Piperazines 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dolutegravir HHV8 Virology Internal medicine Lymphoma Primary Effusion Oxazines Medicine Humans Pharmacology (medical) 030212 general & internal medicine business.industry Remission Induction Chorioretinitis virus diseases Herpesviridae Infections medicine.disease Lymphoma chemistry Anti-Retroviral Agents Positron-Emission Tomography Herpesvirus 8 Human Molecular Medicine business lcsh:RC581-607 Heterocyclic Compounds 3-Ring medicine.drug |
Zdroj: | AIDS Research and Therapy, Vol 16, Iss 1, Pp 1-7 (2019) AIDS Research and Therapy |
ISSN: | 1742-6405 |
Popis: | Background Human herpes virus 8 (HHV8) is the causative agent of Kaposi’s sarcoma and has been associated with an increasing number of hematologic diseases such as primary effusion lymphoma (PEL) (both classic and extracavitary form), multicentric Castleman disease and the germinotropic lymphoproliferative disorder. PEL is a rare B cell non-Hodgkin lymphoma that primarily affects immunocompromised patients; aggressive chemotherapy and antiretroviral therapy (ART) with protease inhibitors have been used, with poor results. We present a case of extracavitary PEL in an HIV-infected patient, regressed after ART initiation. Case presentation A 42-year-old male was admitted to the emergency room because of several months of malaise, fever and progressive deterioration of the general conditions. On physical examination soft non-painful subcutaneous masses were palpable at retronuchal, retroauricolar and thoracic regions. HIV serology resulted positive: HIV plasma viremia was 782,270 copies/mL, CD4 103 cells/mL. The excision of one of the masses, metabolically active at a positron emission tomography (PET-CT) scan, revealed an HHV8-related extracavitary PEL. HHV8 plasma viremia was 44,826 copies/mL. ART with tenofovir alafenamide/emtricitabine/dolutegravir was started together with ganciclovir for cytomegalovirus chorioretinitis. The progressive disappearance of the masses was seen after 6 weeks of ART, and a PET-CT scan resulted completely negative at 3 months. After 19 months of ART the patient was in remission of PEL, HIV viremia was undetectable ( |
Databáze: | OpenAIRE |
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