Sex steroids, sex hormone-binding globulin and levels of N-terminal pro-brain natriuretic peptide in postmenopausal women

Autor: Bart C.J.M. Fauser, Taulant Muka, Joop S.E. Laven, Oscar H. Franco, Eralda Asllanaj, Marija Glisic, Kris G. Vargas, Maryam Kavousi, M. Arfan Ikram, Lyda Z. Rojas
Přispěvatelé: Epidemiology, Obstetrics & Gynecology
Rok vydání: 2018
Předmět:
medicine.medical_specialty
medicine.drug_class
Population
Dehydroepiandrosterone
030204 cardiovascular system & hematology
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
Rotterdam Study
0302 clinical medicine
Sex hormone-binding globulin
Dehydroepiandrosterone sulfate
Sex Hormone-Binding Globulin
Internal medicine
Natriuretic Peptide
Brain
Natriuretic peptide
Humans
Medicine
030212 general & internal medicine
Gonadal Steroid Hormones
education
Testosterone
Aged
Netherlands
education.field_of_study
Estradiol
biology
business.industry
Free androgen index
Middle Aged
Peptide Fragments
Postmenopause
Cross-Sectional Studies
Endocrinology
chemistry
Androgens
biology.protein
Female
Cardiology and Cardiovascular Medicine
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: International Journal of Cardiology, 261, 189-195. Elsevier Ireland Ltd
ISSN: 0167-5273
Popis: Background Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) has a well-documented prognostic value for cardiovascular disease and sex-hormones are suggested to modulate NT-proBNP levels. Objective To examine whether endogenous sex-hormones and sex hormone-binding globulin (SHBG) are associated with NT-proBNP levels in postmenopausal women free of clinical cardiovascular diseases. Methods Total estradiol (E 2 ), total testosterone (TT), androstenedione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and NT-proBNP were assessed in 4112 postmenopausal women free of cardiovascular diseases from the prospective population-based Rotterdam Study. Free androgen index (FAI) was calculated as ratio of TT to SHBG concentration. TT, AD, DHEA(S), SHBG, FAI and NT-proBNP were natural log transformed. Regression coefficients and 95% Confidence Intervals (CI) were calculated using multivariable linear regression models adjusting for confounders. Results In models adjusted for multiple confounders (age, reproductive, life style and cardiovascular risk factors) higher SHBG (per 1 SD increase, β = 0.15, 95% CI = 0.12, 0.18), and lower levels of TT (per 1 SD increase, β = −0.05, 95%CI = −0.08, −0.02), FAI (per 1 SD increase, β = −0.13, 95%CI = −0.15, −0.09), DHEAS (per 1 SD increase, β = −0.06, 95% CI = −0.09, −0.04) and DHEA (per 1 SD increase, β = −0.06, 95%CI = −0.09, −0.04) were associated with higher levels of NT-proBNP. However, no consistent association was found between E 2 and AD and NT-proBNP levels. Additionally, stratification by BMI did not affect any of observed associations. Conclusion Our findings support the hypothesis that higher androgens might be associated with lower natriuretic peptide levels in postmenopausal women.
Databáze: OpenAIRE
Externí odkaz: