Sex steroids, sex hormone-binding globulin and levels of N-terminal pro-brain natriuretic peptide in postmenopausal women
Autor: | Bart C.J.M. Fauser, Taulant Muka, Joop S.E. Laven, Oscar H. Franco, Eralda Asllanaj, Marija Glisic, Kris G. Vargas, Maryam Kavousi, M. Arfan Ikram, Lyda Z. Rojas |
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Přispěvatelé: | Epidemiology, Obstetrics & Gynecology |
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
medicine.drug_class Population Dehydroepiandrosterone 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences chemistry.chemical_compound Rotterdam Study 0302 clinical medicine Sex hormone-binding globulin Dehydroepiandrosterone sulfate Sex Hormone-Binding Globulin Internal medicine Natriuretic Peptide Brain Natriuretic peptide Humans Medicine 030212 general & internal medicine Gonadal Steroid Hormones education Testosterone Aged Netherlands education.field_of_study Estradiol biology business.industry Free androgen index Middle Aged Peptide Fragments Postmenopause Cross-Sectional Studies Endocrinology chemistry Androgens biology.protein Female Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists |
Zdroj: | International Journal of Cardiology, 261, 189-195. Elsevier Ireland Ltd |
ISSN: | 0167-5273 |
Popis: | Background Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) has a well-documented prognostic value for cardiovascular disease and sex-hormones are suggested to modulate NT-proBNP levels. Objective To examine whether endogenous sex-hormones and sex hormone-binding globulin (SHBG) are associated with NT-proBNP levels in postmenopausal women free of clinical cardiovascular diseases. Methods Total estradiol (E 2 ), total testosterone (TT), androstenedione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and NT-proBNP were assessed in 4112 postmenopausal women free of cardiovascular diseases from the prospective population-based Rotterdam Study. Free androgen index (FAI) was calculated as ratio of TT to SHBG concentration. TT, AD, DHEA(S), SHBG, FAI and NT-proBNP were natural log transformed. Regression coefficients and 95% Confidence Intervals (CI) were calculated using multivariable linear regression models adjusting for confounders. Results In models adjusted for multiple confounders (age, reproductive, life style and cardiovascular risk factors) higher SHBG (per 1 SD increase, β = 0.15, 95% CI = 0.12, 0.18), and lower levels of TT (per 1 SD increase, β = −0.05, 95%CI = −0.08, −0.02), FAI (per 1 SD increase, β = −0.13, 95%CI = −0.15, −0.09), DHEAS (per 1 SD increase, β = −0.06, 95% CI = −0.09, −0.04) and DHEA (per 1 SD increase, β = −0.06, 95%CI = −0.09, −0.04) were associated with higher levels of NT-proBNP. However, no consistent association was found between E 2 and AD and NT-proBNP levels. Additionally, stratification by BMI did not affect any of observed associations. Conclusion Our findings support the hypothesis that higher androgens might be associated with lower natriuretic peptide levels in postmenopausal women. |
Databáze: | OpenAIRE |
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