Stability of Buffered Lidocaine and Epinephrine Used for Local Anesthesia
| Autor: | Mary Swandby, Barbara A. Darcey, Gangaram Ragi, Greg Polzin, Patrick Carey, Paul O. Larson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Epinephrine
Lidocaine medicine.drug_class Drug Storage Pain Dermatology Buffers chemistry.chemical_compound Drug Stability medicine Humans Local anesthesia Neutral ph Pain Measurement Local anesthetic business.industry Temperature Buffer solution Hydrogen-Ion Concentration Drug Combinations Oncology chemistry Anesthesia business Anesthesia Local medicine.drug |
| Zdroj: | The Journal of Dermatologic Surgery and Oncology. 17:411-414 |
| ISSN: | 0148-0812 |
| Popis: | Buffered lidocaine has been recently recommended for local anesthesia, as there is less pain on injection of the buffered solution. Reduced pain on injection of lidocaine and epinephrine buffered to a neutral pH was confirmed in 20 subjects (P less than .01). Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at 25 degrees C. Buffered epinephrine fell to 1.34% of its initial concentration under similar conditions. Buffered lidocaine and epinephrine maintained 94.54% and 82.04%, respectively, of their initial concentrations after 4 weeks when refrigerated at 0-4 degrees C. Both lidocaine and epinephrine maintained greater than 90% concentration 2 weeks after buffering when stored at 0-4 degrees C. This permits batch buffering of lidocaine with epinephrine and storage for periods up to 2 weeks when properly refrigerated. |
| Databáze: | OpenAIRE |
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