Revisiting the systemic lipopolysaccharide mediated neuroinflammation: Appraising the effect of l -cysteine mediated hydrogen sulphide on it
| Autor: | Gaurav Kaithwas, Swetlana Gautam, Jitendra K. Rawat, Abdulaziz S. Al-Saeedan, Subhadeep Roy, Manjari Singh, Varsha Gautam, Uma Devi, Rajnish Kumar Yadav, Mohd Nazam Ansari |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Lipopolysaccharide biology lcsh:RM1-950 Pharmaceutical Science Inflammation Article Nitric oxide 03 medical and health sciences chemistry.chemical_compound Lipoxygenase lcsh:Therapeutics. Pharmacology 030104 developmental biology chemistry Toxicity biology.protein medicine lipids (amino acids peptides and proteins) Cyclooxygenase medicine.symptom Neuroinflammation Cysteine |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 26, Iss 4, Pp 520-527 (2018) |
| ISSN: | 1319-0164 |
| DOI: | 10.1016/j.jsps.2018.02.004 |
| Popis: | The present research was ventured to examine the effect of l-cysteine on neuro-inflammation persuaded by peripheral lipopolysaccharides (LPS, 125 μg/kg, i.p.) administration. No behavioral, biochemical, and inflammatory abnormality was perceived in the brain tissues of experimental animals after LPS administration. l-cysteine precipitated marginal symptoms of toxicity in the brain tissue. Similar pattern of wholesome effect of LPS were perceived when evaluated through the brain tissue fatty acid profile, histopathologically and NF-ĸBP65 protein expression. LPS was unsuccessful to alter the levels of hydrogen sulphide (H2S), cyclooxygenase (COX) and lipoxygenase (LOX) enzyme in brain tissue. LPS afforded significant peripheral toxicity, when figured out through inflammatory markers (COX, LOX), gaseous signaling molecules nitric oxide (NO), H2S, liver toxicity (SGOT, SGPT), and inflammatory transcription factor (NF-ĸBP65) and l-cysteine also provided a momentous protection against the same as well. The study inculcated two major finding, firstly LPS (i.p.) cannot impart inflammatory changes to brain and secondly, l-cysteine can afford peripheral protection against deleterious effect of LPS (i.p.) Keywords: Hydrogen sulphide, l-cysteine, Inflammation, Lipopolysaccharide, Neuroinflammation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|