Potential Role of MicroRNAs in the Regulation of Antiviral Responses to Influenza Infection
| Autor: | Thi Hiep Nguyen, Xiaoming Liu, Zhen Zhong Su, Alan Chen-Yu Hsu, Paul S. Foster, Ming Yang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Cellular differentiation viruses Immunology Endogeny Review Biology Virus influenza virus 03 medical and health sciences 0302 clinical medicine microRNA Gene expression Immunology and Allergy Host (biology) RNA Virology immune responses infection 030104 developmental biology Viral replication inflammation 030220 oncology & carcinogenesis lcsh:RC581-607 |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 9 (2018) |
| ISSN: | 1664-3224 |
| Popis: | Influenza is a major health burden worldwide and is caused by influenza viruses that are enveloped and negative stranded RNA viruses. Little progress has been achieved in targeted intervention, either at a population level or at an individual level (to treat the cause), due to the toxicity of drugs and ineffective vaccines against influenza viruses. MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in gene expression, cell differentiation, and tissue development and have been shown to silence viral replication in a sequence-specific manner. Investigation of these small endogenous nucleotides may lead to new therapeutics against influenza virus infection. Here, we describe our current understanding of the role of miRNAs in host defense response against influenza virus, as well as their potential and limitation as new therapeutic approaches. |
| Databáze: | OpenAIRE |
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