The effect of nebulised pentamidine on the concentration of intra-oral Candida albicans in HIV-infected patients
| Autor: | Philip-John Lamey, TW Macfarlane, J. Y. Sirel, Anita Nolan, T. C. Aitchison, J. Shaw |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Pentamidine Isethionate medicine.medical_treatment HIV Infections Microbiology Gastroenterology Candidiasis Oral Internal medicine Immunopathology Administration Inhalation Candida albicans medicine Humans Prospective Studies Sida Prospective cohort study Pentamidine Aerosols Chemotherapy biology business.industry Mouth Mucosa General Medicine Middle Aged biology.organism_classification Corpus albicans stomatognathic diseases Carrier State Immunology Female business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 41:95-97 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/00222615-41-2-95 |
| Popis: | This prospective study investigated whether oral candidal carriage in HIV-infected patients was altered by pentamidine therapy. Repeated oral rinses were taken from 56 HIV-positive patients over a 2-year period. Oral candidal carriage was investigated in two groups of patients, one receiving prophylactic pentamidine therapy and the other not receiving regular prophylaxis. Patients receiving pentamidine had lower concentrations of Candida albicans intra-orally than patients who did not receive it. Furthermore, patients who received pentamidine at one stage of the study, but not another, also had lower concentrations of C. albicans intra-orally when receiving pentamidine. These findings indicate that pentamidine is useful as a local agent for prophylaxis against intra-oral candidosis in HIV-infected patients. |
| Databáze: | OpenAIRE |
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