COVID-19-Associated Pulmonary Aspergillosis at an Academic Medical Center in the Midwestern United States

Autor: Anastasia Wasylyshyn, G Rostyslaw Wasylyshyn, Marisa H. Miceli, Kathleen A Linder
Rok vydání: 2021
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Veterinary (miscellaneous)
030106 microbiology
Applied Microbiology and Biotechnology
Microbiology
Midwestern United States
law.invention
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
High morbidity
Galactomannan
chemistry.chemical_compound
0302 clinical medicine
law
Internal medicine
Epidemiology
medicine
Humans
Aspergillosis
Aged
Retrospective Studies
Aged
80 and over
Academic Medical Centers
medicine.diagnostic_test
business.industry
COVID-19
CAPA
Pneumonia
Middle Aged
Tracheal aspirate
Intensive care unit
Intensive Care Units
Pulmonary aspergillosis
Bronchoalveolar lavage
chemistry
Female
Original Article
Pulmonary Aspergillosis
business
Agronomy and Crop Science
Zdroj: Mycopathologia
ISSN: 1573-0832
0301-486X
DOI: 10.1007/s11046-021-00564-y
Popis: Pulmonary aspergillosis has been reported at high rates in patients with coronavirus disease 2019 (COVID-19) and is associated with high morbidity and mortality. We retrospectively assessed all patients admitted to an intensive care unit during the early COVID-19 surge (3/17/20–5/10/20) at our medical center in the midwestern USA for the presence of COVID-19-associated pulmonary aspergillosis (CAPA). Patients were not routinely screened for CAPA; diagnostic work-up for fungal infections was pursued when clinically indicated. Among 256 patients admitted to the ICU with severe COVID-19, 188 (73%) were intubated and 62 (24%) ultimately expired within 30 days of admission to the ICU. Only three patients (1%) were found to have CAPA; diagnosis was made by tracheal aspirate cultures in two cases and by bronchoalveolar lavage fluid Aspergillus galactomannan in one case. None of the patients who developed CAPA had classic risk factors for invasive fungal infection. The occurrence of CAPA was much lower than that reported at other centers, likely reflecting the local epidemiology.
Databáze: OpenAIRE
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