Protective Effects of Nicorandil on Cardiac Function and Left Ventricular Remodeling in a Rat Model of Ischemic Heart Failure
| Autor: | Yan Wang, Xin Wang, Xizan Yue, Yanqiu Xing, Congcong Liu, Huan-Liang Wang, Wenhua Zhang, Xia Zhang, Zhonggang Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Cardiotonic Agents Heart Ventricles Rat model Myocardial Ischemia 030204 cardiovascular system & hematology Muscle hypertrophy Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine Animals Medicine In patient Nicorandil Ventricular remodeling bcl-2-Associated X Protein Heart Failure Ventricular Remodeling business.industry Myocardium General Medicine medicine.disease Rats cardiovascular system Cardiology business Ischemic heart 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Archives of Medical Research. 49:583-587 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2018.12.006 |
| Popis: | Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure and the potential mechanisms remain unclear. In this study, we investigated the effects of nicorandil on cardiac function, LV remodeling, and Bax expression in myocardium of LV in rats with ischemic heart failure. We found that nicorandil could improve not only the general condition, but also the cardiac function in rats with ischemic heart failure. The data also demonstrated that nicorandil reduced the hypertrophy and fibrosis of LV in rats with ischemic heart failure. Furthermore, nicorandil suppressed the protein level of Bax expression in LV myocardium. Taken together, these results suggest that nicorandil exerts its cardioprotective effect and improves LV remodeling in rats with ischemic heart failure. The mechanism might be relative to the inhibitory effect of nicorandil on the protein level of Bax expression in LV myocardium. |
| Databáze: | OpenAIRE |
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