Identification and Characterization of a Major Cell Wall-Associated Iron-Regulated Envelope Protein (Irep-28) in Mycobacterium tuberculosis
| Autor: | Manjula Sritharan, Friedrich Altmann, Veena C. Yeruva, V. Lakshmi, Daniel Kolarich, Sridevi Duggirala |
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| Rok vydání: | 2006 |
| Předmět: |
Microbiology (medical)
Siderophore Tuberculosis Iron Molecular Sequence Data Clinical Biochemistry Immunology Drug target Cell Mycobactin Microbiology Mycobacterium tuberculosis Cell wall Bacterial Proteins Cell Wall Iron-Binding Proteins medicine Humans Immunology and Allergy Amino Acid Sequence Oxazoles biology medicine.disease biology.organism_classification DNA-Binding Proteins medicine.anatomical_structure Periplasmic Binding Proteins biology.protein Microbial Immunology Antibody Bacterial Outer Membrane Proteins |
| Zdroj: | Clinical and Vaccine Immunology. 13:1137-1142 |
| ISSN: | 1556-679X 1556-6811 |
| DOI: | 10.1128/cvi.00125-06 |
| Popis: | Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein ( hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target. |
| Databáze: | OpenAIRE |
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