Long-term PT-INR levels and the clinical events in the patients with non-valvular atrial fibrillation: A special reference to low-intensity warfarin therapy
| Autor: | Koichi Fuse, Akira Yamashina, Minoru Takahashi, Yoshio Ikeda, Masayuki Goto, Ken Takarada, Masaaki Okabe, Hitoshi Kitazawa, Atsushi Saito, Yoshifusa Aizawa, Ken Toba, Hirooki Matsushita, Hiroshi Abe, Satoru Fujita, Takeo Oguro, Masahito Sato |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Risk medicine.medical_specialty Time Factors Embolism Warfarin therapy Sex Factors Head Injuries Closed Internal medicine medicine Humans International Normalized Ratio cardiovascular diseases Stroke Aged Cerebral Hemorrhage Retrospective Studies Aged 80 and over business.industry Age Factors Warfarin Anticoagulants Atrial fibrillation Middle Aged medicine.disease Intensity (physics) Blunt trauma Heart failure Concomitant Prothrombin Time Cardiology Drug Therapy Combination Female business Cardiology and Cardiovascular Medicine Platelet Aggregation Inhibitors Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Cardiology. 64(2):127-132 |
| ISSN: | 0914-5087 |
| DOI: | 10.1016/j.jjcc.2013.11.015 |
| Popis: | BackgroundAnticoagulation therapy is essential in atrial fibrillation (AF), and in Japan, less intense control is popular.PurposeTo assess the efficacy and safety with a special reference to low intensity warfarin therapy.Subjects and methodsIn 488 out of 508 patients with non-valvular AF, prothrombin time-international normalized ratio (PT-INR) was kept at 1.6–2.59, and they were followed for 49.5 months: 2098 person-years. The mean age was 73.7±9.9 years and 62% were male. The patients were divided by age: ≥70 years and 2.61 in 40.0% with major bleeding at the time of the events. Blunt trauma and concomitant use of antiplatelets were risks for intracranial hemorrhage in the patients ≥70 years.ConclusionsThe event rates were similar between the low- (1.6–1.99) and high- (2.0–2.59) intensity warfarin therapy groups in aged patients |
| Databáze: | OpenAIRE |
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