Polyamines reduces lipid peroxidation induced by different pro-oxidant agents
| Autor: | Graciela Fonini, Gerusa Duarte Dalmolin, Nádia Aléssio Velloso Bellé, Maribel Antonello Rubin, João Rocha |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Nitroprusside
Antioxidant Spermidine Iron medicine.medical_treatment Biguanides Spermine Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation chemistry.chemical_compound medicine TBARS Animals Rats Wistar Molecular Biology Edetic Acid General Neuroscience Biogenic Polyamines Quinolinic Acid Oxidants Pro-oxidant Free radical scavenger Rats chemistry Biochemistry Lipid Peroxidation Neurology (clinical) Dizocilpine Maleate Polyamine Developmental Biology |
| Zdroj: | Brain Research. 1008:245-251 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2004.02.036 |
| Popis: | Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe +2 ) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the free radical and/or aldehyde scavenger effects of polyamines spermine and spermidine on thiobarbituric acid reactive species (TBARS) production induced by QA, SNP, Fe +2 /EDTA system and free Fe 2+ in rat brain. Spermine and spermidine inhibited QA-induced TBARS production; however spermine was a better antioxidant than spermidine. Spermine also inhibited SNP-, Fe +2 /EDTA- and free Fe 2+ -induced TBARS production, but had a modest effect. Spermidine, in turn, also discreetly inhibited SNP-, Fe +2 /EDTA- and free Fe 2+ -induced TBARS production. In the presence of MK-801, QA-induced TBARS production was considerably more inhibited by polyamines. In addition, arcaine does not affect the reducer effect of polyamines. The present findings suggest that the observed effects of polyamines are not related to the activation of NMDA receptor but with their antioxidant and free radical scavenger properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect