A negative double-blind controlled trial of sequential bilateral rTMS in the treatment of bipolar depression
| Autor: | David Elliot, Kate E. Hoy, Lenore E. Wambeek, Susan McQueen, Paul B. Fitzgerald, Zafiris J. Daskalakis |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent medicine.medical_treatment behavioral disciplines and activities law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Physical medicine and rehabilitation Randomized controlled trial Double-Blind Method law Rating scale mental disorders medicine Humans Bipolar disorder Young adult Prefrontal cortex Depression (differential diagnoses) Aged Middle Aged medicine.disease Transcranial Magnetic Stimulation 030227 psychiatry Transcranial magnetic stimulation Psychiatry and Mental health Clinical Psychology Treatment Outcome Female Psychology Treatment-resistant depression 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of affective disorders. 198 |
| ISSN: | 1573-2517 |
| Popis: | Background/Objective To explore the therapeutic benefit of sequential bilateral repetitive transcranial magnetic stimulation (rTMS) in the treatment of bipolar depression. Method A 2 arm randomized controlled parallel design trial comparing the use of active sequential bilateral rTMS to a sham form of stimulation in 49 patients with bipolar disorder and treatment resistant depression. Results There was no significant difference in mean reduction in depression rating scale scores or response rates between active and sham stimulation. Limitations The study was of limited sample size and the use of bilateral rTMS limited generalizability to other forms of rTMS. Conclusions This study provides no support to the use of active sequential bilateral rTMS in the treatment of the depressive phase of bipolar affective disorder. Although this result is not definitive, we suggest that future research may be better focused on trials evaluating the use of unilateral types of rTMS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect