Cryotherapeutic ablation of liver tumours
| Autor: | G J Poston, D.J. Sherlock, A J Sheen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Adolescent medicine.medical_treatment Rectum Cryotherapy Cryosurgery Metastasis Hemoglobins Carcinoembryonic antigen medicine Humans Aged Retrospective Studies Aged 80 and over Chemotherapy biology business.industry Liver Neoplasms Cryoablation Liver tumours Middle Aged medicine.disease Ablation Survival Analysis Surgery Carcinoembryonic Antigen Carcinoma Neuroendocrine medicine.anatomical_structure biology.protein Female business Colorectal Neoplasms Follow-Up Studies |
| Zdroj: | The British journal of surgery. 89(11) |
| ISSN: | 0007-1323 |
| Popis: | Background This paper reports a 7-year experience of cryoablation for colorectal and non-colorectal liver metastases. Methods A retrospective review was undertaken of patients treated in two adjacent UK centres in the north-west of England. Results Over a 7-year period (1993–2000), 57 patients underwent cryotherapy for malignant hepatic tumours (41 colorectal, 16 non-colorectal). In the patients with colorectal metastases, preoperative carcinoembryonic antigen (CEA) levels fell significantly, from a mean of 444·1 to 6·22 µg/l (P = 0·002). One patient died, two developed cryoshock and six had cardiorespiratory complications. All patients with colorectal metastases subsequently received 5-fluorouracil-based chemotherapy. The remaining 16 patients with non-colorectal tumours (seven neuroendocrine metastases, five hepatocellular carcinomas, three sarcomas, one cholangiocarcinoma) all received cryotherapy alone, with no major complications. The median survival for patients with non-colorectal metastases was 37 months, compared with 22 months for those with colorectal metastases (P = 0·005). Conclusion Hepatic cryotherapy is effective and safe, as demonstrated by the significant reduction in postoperative CEA concentration and the low risk of complications. However, this initial short-term success was not reflected in 5-year survival rates. Cryotherapy for non-colorectal metastases had a greater long-term survival benefit and is a useful means of controlling symptoms. |
| Databáze: | OpenAIRE |
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