Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

Autor: Merete Nordentoft, Alison R. Yung, Gregor Berger, Monika Schlögelhofer, Ian B. Hickie, Anita Riecher-Rössler, Lieuwe de Haan, Swapna Verma, Robert Hester, Dorien H. Nieman, Miriam R. Schäfer, Barnaby Nelson, Patrick D. McGorry, Maximus Berger, Andrew Thompson, G. Paul Amminger, Connie Markulev, Nilufar Mossaheb, Alison McLaverty, Hok Pan Yuen, Stefan Smesny, Kelly Allott, Eric Y.H. Chen
Přispěvatelé: Adult Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, University of Zurich, Amminger, G Paul
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Psychosis
2921 Psychiatric Mental Health
Adolescent
omega
neurocognition
Population
610 Medicine & health
high risk
ultra-high risk
2738 Psychiatry and Mental Health
03 medical and health sciences
ultra
Cognition
0302 clinical medicine
poly
Fatty Acids
Omega-3
medicine
Humans
Verbal fluency test
education
poly-unsaturated fatty acids
Biological Psychiatry
chemistry.chemical_classification
education.field_of_study
business.industry
10058 Department of Child and Adolescent Psychiatry
medicine.disease
Eicosapentaenoic acid
030227 psychiatry
Psychiatry and Mental health
Memory
Short-Term
Psychotic Disorders
chemistry
Schizophrenia
Phychiatric Mental Health
sense organs
omega-3
Pshychiatric Mental Health
business
2803 Biological Psychiatry
Neurocognitive
unsaturated fatty acids
030217 neurology & neurosurgery
Clinical psychology
Polyunsaturated fatty acid
Zdroj: Mclaverty, A, Allott, K A, Berger, M, Hester, R, Mcgorry, P D, Nelson, B, Markulev, C, Yuen, H P, Schäfer, M R, Mossaheb, N, Schlögelhofer, M, Smesny, S, Hickie, I B, Berger, G E, Chen, E Y H, Haan, L, Nieman, D H, Nordentoft, M, Riecher-rössler, A, Verma, S, Thompson, A, Yung, A R & Amminger, G P 2021, ' Omega-3 fatty acids and neurocognitive ability in young people at ultra-high risk for psychosis ', Early Intervention in Psychiatry, vol. 15, no. 4, pp. 874-881 . https://doi.org/10.1111/eip.13025
Early intervention in psychiatry, 15(4), 874-881. Wiley-Blackwell
ISSN: 1751-7885
Popis: Background Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations. Method Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking. Results Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007). Conclusions The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.
Databáze: OpenAIRE
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