Sodium fluoride influences calcium metabolism resulting from the suppression of osteoclasts in the scales of nibbler fish Girella punctata
| Autor: | Masayuki Sato, Koji Yachiguchi, Keiichi Motohashi, Yukio Yaguchi, Yoshiaki Tabuchi, Yoichiro Kitani, Takahiro Ikari, Shouzo Ogiso, Toshio Sekiguchi, Tran Ngoc Hai, Do Thi Thanh Huong, Nguyen Viet Hoang, Makoto Urata, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
inorganic chemicals Osteoblasts Sodium fluoride technology industry and agriculture Osteoclasts Scales 010501 environmental sciences Aquatic Science Element analysis 01 natural sciences body regions 03 medical and health sciences 030104 developmental biology Calcium metabolism Nibbler fish 0105 earth and related environmental sciences |
| Zdroj: | Fisheries Science. 83(4):543-550 |
| ISSN: | 0919-9268 |
| Popis: | The influence of sodium fluoride (NaF) on calcium metabolism was examined in nibbler fish (marine teleosts). Two days after the administration of NaF (5 μg/g of body weight) (around 10−4 M in fish), we showed that plasma calcium levels significantly decreased in NaF-treated nibbler fish. In addition, we detected fluoride in the treated scales by use of a scanning electron microscope with an energy-dispersive X-ray microanalysis, indicating that NaF directly affects their scales. Therefore, the influence of NaF on osteoblasts and osteoclasts in the scales was examined. In the scales of NaF-injected nibbler fish, tartrate-resistant acid phosphatase (TRAP) (osteoclastic marker enzyme) decreased, although alkaline phosphatase (osteoblastic marker enzyme) was activated. To confirm the effect of NaF on osteoclasts, furthermore, the mRNA expressions of osteoclastic markers (matrix metalloproteinase-9 and TRAP) were decreased significantly 2 days after incubation. In barred knifejaws, plasma calcium levels decreased as they did in nibbler fish. Therefore, NaF functions in both osteoblasts and osteoclasts and then influences calcium metabolism in marine fish. In the marine environment, high levels of fluoride (1.2–1.5 mg F−/l) (around 10−5–10−4 M) are present in seawater. It is probable that teleosts living in seawater efficiently use fluoride to regulate their blood calcium levels. © 2017 Japanese Society of Fisheries Science 出版者照会後に全文公開 / Embargo Period 12 months Erratum to: Sodium fluoride influences calcium metabolism resulting from the suppression of osteoclasts in the scales of nibbler fish Girella punctata (Fish Sci, 10.1007/s12562-017-1086-0)( https://link.springer.com/article/10.1007%2Fs12562-017-1092-2 |
| Databáze: | OpenAIRE |
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