Preserved bone mass in ovariectomized rats treated with parathyroid-hormone-related peptide (1-34) and (107-111) fragments
| Autor: | Véronique Coxam, Jean-Pierre Barlet, J. Rouffet, N. Gaumet |
|---|---|
| Přispěvatelé: | Laboratoire de recherches sur la croissance et les métabolismes des herbivores, Institut National de la Recherche Agronomique (INRA), Revues Inra, Import |
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Ovariectomy Biology Dry weight Osteoclast Internal medicine [SDV.BDD] Life Sciences [q-bio]/Development Biology Parathyroid hormone-related peptide medicine Animals Femur Rats Wistar [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology Dose-Response Relationship Drug Parathyroid Hormone-Related Protein Proteins Biological activity PTMRH Peptide Fragments Rats [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition medicine.anatomical_structure Endocrinology Parathyroid Hormone [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies Ovariectomized rat Osteoporosis RAT Female Cortical bone Densitometry hormones hormone substitutes and hormone antagonists |
| Zdroj: | Reproduction Nutrition Development Reproduction Nutrition Development, EDP Sciences, 1994, 34 (1), pp.473-481 |
| ISSN: | 0926-5287 1297-9708 |
| DOI: | 10.1051/rnd:19940508 |
| Popis: | The effect of synthetic human PTHrP (1-34) or (107-111) fragments on bone loss was studied in rats, one month after ovariectomy (OVX). Four groups of 7-8-month-old rats were treated sc daily for 13 d with PTHrP (1-34) or (107-111) at the dose of 1 or 3 nmol/100 g body weight. Sham-operated (SHO) and control OVX rats received solvent alone. In our conditions, at the lowest dose, neither (1-34) nor (107-111) fragments had any significant effect. However, at the dose of 3 nmol/100 g daily for 13 d both treatments significantly increased femoral dry weight, ash weight, Ca content and densitometry of the femur. The effect of PTHrP (1-34) mainly resulted from increased cortical and trabecular bone (% recovery: 98.25 and 105.23%, respectively). For the PTHrP (107-111) fragment, a positive effect was only demonstrated on the cortical bone (98.25% recovery). The results of this study demonstrate that both hPTHrP (1-34) and (107-111, osteostatin) fragments are positive for bone when administered at the dose of 3 nmol/100 g body weight/d for 13 d to adult OVX rats. |
| Databáze: | OpenAIRE |
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