Exploring membrane respiratory chains
| Autor: | Filipa Calisto, Paulo J. Castro, Manuela M. Pereira, Bruno C. Marreiros, Miguel Teixeira, Andreia F. Silva, Patrícia N. Refojo, Afonso M.S. Duarte, Filipe M. Sousa, Filipa V. Sena |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Archaeal Proteins 030106 microbiology Biophysics Biochemistry Mitochondrial Proton-Translocating ATPases Cell membrane Electron Transport 03 medical and health sciences Quinone Reductases Bacterial Proteins medicine Ion transporter Membrane potential ATP synthase biology Bacteria Chemistry Cell Membrane Quinones Cell Biology Electron transport chain Archaea Transmembrane protein medicine.anatomical_structure Electron Transport Chain Complex Proteins biology.protein Oxidoreductases Oxidation-Reduction |
| Zdroj: | Biochimica et biophysica acta. 1857(8) |
| ISSN: | 0006-3002 |
| Popis: | Acquisition of energy is central to life. In addition to the synthesis of ATP, organisms need energy for the establishment and maintenance of a transmembrane difference in electrochemical potential, in order to import and export metabolites or to their motility. The membrane potential is established by a variety of membrane bound respiratory complexes. In this work we explored the diversity of membrane respiratory chains and the presence of the different enzyme complexes in the several phyla of life. We performed taxonomic profiles of the several membrane bound respiratory proteins and complexes evaluating the presence of their respective coding genes in all species deposited in KEGG database. We evaluated 26 quinone reductases, 5 quinol:electron carriers oxidoreductases and 18 terminal electron acceptor reductases. We further included in the analyses enzymes performing redox or decarboxylation driven ion translocation, ATP synthase and transhydrogenase and we also investigated the electron carriers that perform functional connection between the membrane complexes, quinones or soluble proteins. Our results bring a novel, broad and integrated perspective of membrane bound respiratory complexes and thus of the several energetic metabolisms of living systems. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|