Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
| Autor: | Lisa M. Saksida, Timothy J. Bussey, Mandy Johnstone, Douglas Blackwood, Seth G. N. Grant, Andrew McKechanie, Jess Nithianantharajah, T. J. Stewart, D. St Clair |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male DNA Copy Number Variations Spatial Learning Disease Biology Bioinformatics Article law.invention 03 medical and health sciences Tumor suppressor proteins User-Computer Interface Young Adult 0302 clinical medicine Touchscreen law Animals Humans Diagnosis Computer-Assisted 030304 developmental biology Homologous gene Mice Knockout 0303 health sciences Multidisciplinary Sequence Homology Amino Acid Tumor Suppressor Proteins Cognition Middle Aged Cognitive test Mice Inbred C57BL Sequence homology Case-Control Studies Protein Biosynthesis Mutation Spatial learning Schizophrenia Female Cognition Disorders Neuroscience Guanylate Kinases 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | Brain and Mind Institute Researchers' Publications Scientific Reports Nithianantharajah, J, McKechanie, A G, Stewart, T J, Johnstone, M, Blackwood, D H, St Clair, D, Grant, S G N, Bussey, T J & Saksida, L M 2015, ' Bridging the translational divide : identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene ', Scientific Reports, vol. 5, pp. 14613 . https://doi.org/10.1038/srep14613 |
| DOI: | 10.1038/srep14613 |
| Popis: | Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic. |
| Databáze: | OpenAIRE |
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