Production of magnetic multilamellar liposomes as highly T(2)-efficient MRI contrast agents
| Autor: | Olivier Lambert, Gérard Raffard, Etienne Duguet, Chrystel Faure, Jean-Michel Franconi, Marie-Edith Meyre |
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| Přispěvatelé: | Centre de recherches Paul Pascal (CRPP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique des systèmes biologiques (CRMSB), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université de Bordeaux (UB), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Materials science
media_common.quotation_subject Biomedical Engineering Contrast Media Metal Nanoparticles Pharmaceutical Science Medicine (miscellaneous) Nanoparticle Bioengineering 02 engineering and technology 010402 general chemistry Ferric Compounds 01 natural sciences chemistry.chemical_compound Nuclear magnetic resonance Microscopy Electron Transmission medicine Contrast (vision) General Materials Science media_common Liposome medicine.diagnostic_test Cryoelectron Microscopy Multilamellar liposomes Magnetic resonance imaging [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Magnetic Resonance Imaging 3. Good health 0104 chemical sciences chemistry T2 relaxation Liposomes Molecular Medicine Molecular imaging 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Nanomedicine Nanomedicine, Future Medicine, 2011, 7 (1), pp.18-21. ⟨10.1016/j.nano.2010.10.011⟩ |
| ISSN: | 1743-5889 1748-6963 |
| DOI: | 10.1016/j.nano.2010.10.011⟩ |
| Popis: | International audience; Lipid-based multilamellar vesicles loaded with aminosilane-modified maghemite nanoparticles (a-MNPs), also called magnetonions (MO), were analyzed for their magnetic resonance imaging (MRI) contrast agent properties. They were shown to be better T(2)-MRI contrast agents than commercial contrast agents and other reported liposome-based contrast agents as shown by their higher value of relaxivity ratio (r(2)/r(1) = 17), although a lower magnetic field intensity was used (0.2 T). Their high efficiency was explained by the aggregation of a-MNPs in between multilamellar vesicles, bilayers induced by MO preparation, and evidenced by cryo-TEM imaging. Magnetonions are then a promising platform for diagnosis and therapy. FROM THE CLINICAL EDITOR: In this study, magnetonions (MO) are presented as a very potent T2 relaxation enhancing MRI contrast agents. Such agents may be used in cell labeling and molecular imaging applications. |
| Databáze: | OpenAIRE |
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