Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis
| Autor: | Dost Öngür, Gregor Leicht, Jaelin Rippe, Mahmut Yüksel, Michael Murphy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Psychosis medicine.medical_treatment Population Mismatch negativity Audiology Electroencephalography behavioral disciplines and activities Article First episode psychosis medicine Humans education Antipsychotic Biological Psychiatry education.field_of_study medicine.diagnostic_test business.industry Brain medicine.disease Psychiatry and Mental health medicine.anatomical_structure Acoustic Stimulation Psychotic Disorders Occipital scalp Scalp Evoked Potentials Auditory business Biomarkers Antipsychotic Agents |
| Zdroj: | J Psychiatr Res |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2021.09.034 |
| Popis: | Decreased mismatch negativity (MMN) is a proposed biomarker for psychotic disorders. However, the magnitude of the effect appears to be attenuated in first-episode populations. Furthermore, how mismatch negativity amplitudes are related to brain connectivity in this population is unclear. In this study, we used high-density EEG to record duration-deviant MMN from 22 patients with first-episode psychosis (FEP) and 23 age-matched controls (HC). Consistent with past work, we found decreased MMN amplitude in FEP over a large area of the frontal scalp. We also found decreased latency over the occipital scalp. MMN amplitude was negatively correlated with antipsychotic dose. We used Granger causality to investigate directional connectivity between frontal, midline, left, and right scalp during MMN and found reduced connectivity in FEP compared to HC and following deviant stimuli compared to standard stimuli. FEP participants with smaller decreases in connectivity from standard to deviant stimuli had worse disorganization symptoms. On the other hand, connectivity from the front of the scalp following deviant stimuli was relatively preserved in FEP compared to controls. Our results suggest that a relative imbalance of bottom-up and top-down perceptual processing is present in the early stages of psychotic disorders. |
| Databáze: | OpenAIRE |
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