Drug-specific EEG frequency spectra and their time courses produced in the cat by antidepressants and a benzodiazepine
| Autor: | M.D Fairchild, C Yale, D.J Jenden, M.R Mickey |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Imipramine
medicine.drug_class Antidepressive Agents Tricyclic Pharmacology Electroencephalography Desipramine medicine Animals Distribution (pharmacology) chemistry.chemical_classification Benzodiazepine Diazepam Dose-Response Relationship Drug medicine.diagnostic_test General Neuroscience Brain Doxepin chemistry Anesthesia Cats Female Neurology (clinical) Psychology Tricyclic medicine.drug |
| Zdroj: | Electroencephalography and Clinical Neurophysiology. 52:81-88 |
| ISSN: | 0013-4694 |
| DOI: | 10.1016/0013-4694(81)90192-9 |
| Popis: | The effects of the tricyclic antidepressants imipramine, desipramine and doxepin and the anti-anxiety agent diazepam were tested for their effects on the frequency distribution of spontaneous brain electrical activity (EEG) in the cat. Multivariate statistical techniques were employed to make an objective and quantitative assessment of the results of broad-band frequency analysis in terms of certain dose-related and drug-specific variables. In spite of several clinical and pharmacological differences in their properties, the antidepressants produced remarkably similar profiles of frequency change which were unrelated to those produced by diazepam. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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