Nanovectorization of DNA Through Cells Using Protamine Complexation
| Autor: | Régis Delage-Mourroux, Fabien Picaud, Tijani Gharbi, Khaoula Boukari, C. Caoduro, Marc Pudlo, Hatem Boulahdour, Nadia Skandrani, Eric Hervouet, Raoudha Kacem, Christophe Borg |
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| Přispěvatelé: | Nanomédecine, imagerie, thérapeutique - UFC (EA 4662) (NIT / NANOMEDECINE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Estrogènes, Expression génique et pathologies du Système Nerveux Central - UFC (E2SNC / ESTROGENES) |
| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular Physiology Molecular Conformation Biophysics Nanoparticle Nanotechnology 02 engineering and technology Carbon nanotube Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences law.invention Molecular dynamics chemistry.chemical_compound Adsorption law Animals Humans [CHIM]Chemical Sciences Molecule Protamines Particle Size ComputingMilieux_MISCELLANEOUS biology Nanotubes Carbon Chemistry Biological Transport DNA Cell Biology 021001 nanoscience & nanotechnology Protamine 0104 chemical sciences biology.protein Nanoparticles Nanocarriers 0210 nano-technology |
| Zdroj: | Journal of Membrane Biology Journal of Membrane Biology, Springer Verlag (Germany), 2016, 249 (4), pp.493-501. ⟨10.1007/s00232-016-9890-5⟩ |
| ISSN: | 1432-1424 0022-2631 |
| Popis: | Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex. |
| Databáze: | OpenAIRE |
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