Noctural dipping status and left ventricular hypertrophy: A cardiac magnetic resonance imaging study

Autor: Mark Hamilton, Jonathan C L Rodrigues, Nathan E Manghat, Iwan Harries, Amardeep Ghosh Dastidar, Julian F. R. Paton, Angus K Nightingale, Laura E K Ratcliffe, Emma C. Hart, Antonio Matteo Amadu, Amy E Burchell
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Ambulatory blood pressure
Endocrinology
Diabetes and Metabolism
Bristol Heart Institute
Magnetic Resonance Imaging
Cine
Subgroup analysis
030204 cardiovascular system & hematology
Nocturnal
Left ventricular hypertrophy
030218 nuclear medicine & medical imaging
Muscle hypertrophy
03 medical and health sciences
0302 clinical medicine
Cardiac magnetic resonance imaging
Internal medicine
Internal Medicine
medicine
Humans
Prospective Studies
ambulatory blood pressure
Antihypertensive Agents
Aged
nocturnal dip
medicine.diagnostic_test
biology
business.industry
Dipper
Magnetic resonance imaging
Hypertrophy
Blood Pressure Monitoring
Ambulatory
Middle Aged
medicine.disease
biology.organism_classification
Circadian Rhythm
Hypertension and the Heart
Hypertension
myocardial strain
Cardiology
Female
Hypertrophy
Left Ventricular
Cardiology and Cardiovascular Medicine
business
Zdroj: J Clin Hypertens (Greenwich)
Rodrigues, J C L, Amadu, A M, Ghosh Dastidar, A, Harries, I, Burchell, A E, Ratcliffe, L E K, Hart, E C, Hamilton, M C K, Paton, J F R, Nightingale, A K & Manghat, N E 2018, ' Noctural dipping status and left ventricular hypertrophy : A cardiac magnetic resonance imaging study ', Journal of Clinical Hypertension, vol. 20, no. 4, pp. 784-793 . https://doi.org/10.1111/jch.13235
ISSN: 1524-6175
DOI: 10.1111/jch.13235
Popis: We investigate the impact of dipper status on cardiac structure with cardiovascular magnetic resonance (CMR). Ambulatory blood pressure monitoring and 1.5T CMR were performed in 99 tertiary hypertension clinic patients. Subgroup analysis by extreme dipper (n = 9), dipper (n = 39), non‐dipper (n = 35) and reverse dipper (n = 16) status was performed, matched in age, gender and BMI. Left ventricular (LV) mass was significantly higher for extreme dippers than dippers after correction for covariates (100 ± 6 g/m(2) vs 79 ± 3 g/m(2), P = .004). Amongst extreme dippers and dippers (n = 48), indexed LV mass correlated positively with the extent of nocturnal blood pressure dipping (R = .403, P = .005). On post‐hoc ANCOVA, the percentage of nocturnal dip had significant effect on indexed LV mass (P = .008), but overall SBP did not (P = .348). In the tertiary setting, we found a larger nocturnal BP drop was associated with more LV hypertrophy. If confirmed in larger studies, this may have implications on nocturnal dosing of anti‐hypertensive medications.
Databáze: OpenAIRE
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