^|^alpha;-Tocopherol Status and Expression of ^|^alpha;-Tocopherol Transfer Protein in Type 2 Diabetic Goto-Kakizaki Rats
| Autor: | Ryuzo Takaya, Kimitaka Takitani, Atsushi Yoden, Hiroshi Miyazaki, Hiroshi Tamai, Maki Koh |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Antioxidant medicine.medical_treatment alpha-Tocopherol Nutritional Status Medicine (miscellaneous) Type 2 diabetes Antioxidants Lipid peroxidation chemistry.chemical_compound Insulin resistance Internal medicine Diabetes mellitus medicine Animals Tocopherol Rats Wistar Nutrition and Dietetics Superoxide Dismutase Vitamin E Rats Inbred Strains medicine.disease Rats Endocrinology Diabetes Mellitus Type 2 Liver chemistry Lipid Peroxidation Carrier Proteins |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 59:64-68 |
| ISSN: | 1881-7742 0301-4800 |
| DOI: | 10.3177/jnsv.59.64 |
| Popis: | Vitamin E, a critical fat-soluble vitamin antioxidant, is expressed on cell membranes and prevents propagation of lipid peroxidation. α-Tocopherol transfer protein (α-TTP) is a cytosolic protein located in the hepatocytes that acts as the principal regulator of the circulating α-tocopherol levels. Type 2 diabetes is a metabolic disorder characterized by hyperglycemia, caused by insulin resistance. Lipid peroxidation promotes the clinical progression and development of complications in type 2 diabetes. Results of animal and human experiments on the vitamin E status in diabetes are conflicting. The present study was conducted with the objective of investigating the vitamin E status and α-TTP expression in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. In diabetic GK rats, increases of the α-tocopherol levels in the plasma and liver were observed as compared with the levels in the controls. No alternation in the CuZn-superoxide dismutase (SOD) or Mn-SOD gene expression was found in the liver of GK rats as compared with that in the controls. The GK rats showed an increase of the hepatic expression of the α-TTP gene as compared with the level in the controls. It can be suggested that the increased hepatic α-TTP gene expression levels may influence plasma α-tocopherol levels in the diabetic animals. Hence, investigation of the regulatory factors of α-TTP expression may provide important clues to highlighting the antioxidant mechanisms of vitamin E. |
| Databáze: | OpenAIRE |
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