Evaluation of the genetic effects of 238Pu incorporated into mice
| Autor: | A.M. Lyaginskaya, V.A. Shevchenko, L.K. Ramaya, G.A. Vilkina, M.D. Pomerantseva |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Ratón Male mice Chromosomal translocation Biology Body weight Translocation Genetic Toxicology Andrology Mice Dominant lethal Pregnancy Testis Animals Fragmentation (cell biology) Spermatogenesis Fetal Death Genes Dominant Chromosome Aberrations Mutagenicity Tests Dose-Response Relationship Radiation General Medicine Organ Size Alpha Particles Plutonium Gamma Rays Female Genes Lethal Dose rate |
| Zdroj: | Mutation research. 226(2) |
| ISSN: | 0027-5107 |
| Popis: | The genetic effects of 238Pu incorporated into male mice were estimated by several tests. The activity of the administered 238Pu nitrate varied from 7 to 1850 Bq/g of body weight. The average alpha-radiation dose absorbed in the testes ranged from 2 to 96 cGy, with a dose rate of 0.004-1 cGy/day. alpha-Radiation from 238Pu was shown to induce dominant lethal mutations (DLM) and reciprocal translocation (RT), chromosomal fragmentation and formation of abnormal sperm heads (ASH). The effect does not depend on the average alpha-radiation dose absorbed in the testis. The relative genetic efficiency of alpha-radiation, as compared with that of chronic alpha-radiation for the indices under study, was about 10-20. |
| Databáze: | OpenAIRE |
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