Free fructose in human cerebrospinal fluid
| Autor: | Wray Hl, Winegrad Ai |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Electrophoresis
medicine.medical_specialty Endocrinology Diabetes and Metabolism Fructose Glucosephosphate Dehydrogenase Neural tissues Nervous System chemistry.chemical_compound Polyol pathway Cerebrospinal fluid Diabetes mellitus Internal medicine Diabetes Mellitus Internal Medicine medicine Humans Hexose chemistry.chemical_classification medicine.disease Glucose Enzyme Endocrinology chemistry Biochemistry Indicators and Reagents Experimental diabetes |
| Zdroj: | Diabetologia. 2:82-85 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | The presence of free fructose in human cerebrospinal fluid has been demonstrated by enzymatic analysis and high voltage paper electrophoresis. In 39 of 40 patients the cerebrospinal fluid fructose concentration exceeded that in plasma. A linear correlation (r = + 0.88) was observed between cerebrospinal fluid fructose and glucose concentrations. Present evidence suggests that neural tissues are the source of cerebrospinal fluid fructose, and that fluctuations in cerebrospinal fluid fructose concentration mirror fluctuations in the neural concentrations of this hexose. These observations suggest that increased activity of the sorbitol pathway may exist in the neural tissues of patients with diabetes mellitus similar to that recently observed in tissue from animals with experimental diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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